Evidence map›Paper›PMID 39107057›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO

Elizabeth C Gonye, Yingtang Shi, Keyong Li, Rachel T Clements, Wenhao Xu, Douglas A Bayliss

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth C GonyeDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.ORCID 0000-0002-3604-6655
Yingtang ShiDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.
Keyong LiDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.
Rachel T ClementsDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903.
Wenhao XuGenetically Engineered Mouse Model Core, University of Virginia, Charlottesville, Virginia 22903.
Douglas A BaylissDepartment of Pharmacology, University of Virginia, Charlottesville, Virginia 22903 dab3y@virginia.edu.ORCID 0000-0002-5630-2572

Funding

TRAINING IN THE PHARMACOLOGICAL SCIENCEST32GM007055 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI LYNCH, KEVIN R. · 1985 to 2022
$7.2M
Retrotrapezoid nucleus and central chemoreceptionR01HL074011 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GUYENET, PATRICE G. · 2003 to 2018
$6.6M
Cellular/Molecular Mechanisms of Respiratory Neuronal ChemosensitivityR01HL108609 · NHLBI · UNIVERSITY OF VIRGINIA · PI Douglas A. Bayliss · 2011 to 2026
$6.5M
Role of presympathetic neurons of the hindbrain in cardiovascular controlR01HL148004 · NHLBI · UNIVERSITY OF VIRGINIA · PI ABBOTT, STEPHEN · 2019 to 2023
$2.6M
Training in the Pharmacological SciencesT32GM148379 · NIGMS · UNIVERSITY OF VIRGINIA · PI Michelle L Bland, Thurl E. Harris · 2023 to 2026
$1.3M
Metabotropic contributions to pH-sensitivity and breathing modulation by RTN chemoreceptorsF31HL154660 · NHLBI · UNIVERSITY OF VIRGINIA · PI GONYE, ELIZABETH CATHERINE · 2020 to 2022
$104k
NHLBI NIH HHS F31 HL154660NHLBI NIH HHS R01 HL074011NHLBI NIH HHS R01 HL108609NHLBI NIH HHS R01 HL148004NIGMS NIH HHS T32 GM007055NIGMS NIH HHS T32 GM148379
6 · The paper itself

Abstract

An interoceptive homeostatic reflex monitors levels of CO

Indexed as

Carbon DioxideNeuronsReceptors, G-Protein-CoupledAnimalsFemaleHydrogen-Ion ConcentrationHypercapniaMaleMiceMice, Inbred C57BLMice, TransgenicPotassium Channels, Tandem Pore DomainProtonsRespirationCarbon DioxideGPR4 protein, mousePotassium Channels, Tandem Pore DomainProtonsReceptors, G-Protein-CoupledbrainstemchemosensationGPR4homeostasisinteroceptionrespiration

Identifiers

PMID39107057
PMCPMC11376338

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.