Evidence map›Paper›PMID 39106888›Full record

ArticleJournal of Korean medical science2024

Type 2 Innate Lymphoid Cells and Skin Fibrosis in a Murine Model of Atopic Dermatitis-Like Skin Inflammation.

Jisun Yoon, Jiho Lee, Arum Park, Jin Yoon, Jeong Ryun Kim, Gyeong Joon Moon, Jinho Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean medical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jisun YoonDepartment of Pediatrics, Chung-Ang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4904-9118
Jiho LeeAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-8609-6386
Arum ParkAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0001-7415-8220
Jin YoonAsan Institute for Life Sciences, Asan Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0003-4355-6888
Jeong Ryun KimDepartment of Cell and Genetic Engineering, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0009-0007-7689-6797
Gyeong Joon Moon *Department of Cell and Genetic Engineering, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2851-9563
Jinho Yu *Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jinhoyu@amc.seoul.kr.ORCID https://orcid.org/0000-0002-1226-8077

Funding

Chung-Ang UniversityNational Research Foundation of Korea 2015R1D1A1A01060084
6 · The paper itself

Abstract

backgroundAtopic dermatitis (AD) is a chronic relapsing inflammatory skin disease. Although murine studies have demonstrated that type 2 innate lymphoid cells (ILCs) mediate type 2 skin inflammation, their role in skin fibrosis in AD remains unclear. This study investigated whether type 2 ILCs are involved in skin fibrosis using an AD-like murine model.

methodsC57BL/6 mice were treated epicutaneously with

resultsThe clinical score and transepidermal water loss (TEWL) were significantly higher in the AD group than in the control group. The AD group also showed significantly increased epidermal and dermal thicknesses and significantly higher numbers of eosinophils, neutrophils, mast cells, and lymphocytes in the lesional skin than the control group. The lesional skin of the AD group showed increased stain of collagen and significantly higher levels of collagen than the control group (10.4 ± 2.2 µg/mg vs. 1.6 ± 0.1 µg/mg,

conclusionIn the

Indexed as

Dermatitis, AtopicDisease Models, AnimalFibrosisHomeodomain ProteinsImmunity, InnateLymphocytesMice, Inbred C57BLSkinAnimalsAspergillus fumigatusCollagenEosinophilsFemaleMast CellsMiceMice, KnockoutCollagenHomeodomain ProteinsRAG-1 proteinAtopic Dermatitis, Mouse ModelSkin FibrosisType 2 Innate Lymphoid Cell

Identifiers

PMID39106888
PMCPMC11301010

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.