ArticleScience signaling2024
Poly-GR repeats associated with ALS/FTD gene
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Article in Science signaling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Glial cell toxicity in a Drosophila C9orf72 neurodegeneration model.PLoS genetics · 2026Article
- The Interactions of Tau, RNA, and Stress Granules in Neurodegenerative Disease: A Comprehensive Review.Cells · 2026Review
- Microglial Dysfunction Induced by C9ORF72 Dipeptide Repeat Proteins: Biomarker and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Hyperoside protects against poly-GR-mediated neurodegeneration via regulation of mitochondrial fission and oxidative stress in C9orf72-associated ALS.Chinese medicine · 2026Article
- Article
- Poly-GR promotes ferroptosis-associated vulnerability in C9orf72-ALS.Cell & bioscience · 2026Article
- Lysosomal homeostasis at the crossroads of neurodegeneration.The Journal of clinical investigation · 2026Review
- Lisinopril activates BI1 to reprogram lipid metabolism and restore autophagy in ALS.Communications biology · 2026Article
- Dysregulated neuronal mRNA transport and translation in FTD/ALS.NPJ dementia · 2026Review
- Translation elongation: measurements and applications.RNA biology · 2025Review
- PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease.Acta neuropathologica · 2025Article
- Glial cell-intrinsic and non-cell autonomous toxicity in a Drosophila C9orf72 neurodegeneration model.bioRxiv : the preprint server for biology · 2025Article
- Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy.EMBO molecular medicine · 2025Article
- Cell cycle regulation by the ribotoxic stress response.Trends in cell biology · 2025Review
- Targeting GeneInternational journal of molecular sciences · 2025Review
- RNA dysregulation in neurodegenerative diseases.The EMBO journal · 2025Review
- Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathy.Cell reports · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Daoyuan DongDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0000-6892-4857
Zhe ZhangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-3952-2722
Yini LiDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2213-0650
Malgorzata J LatalloDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Shaopeng WangDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Blake NelsonDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-0678-1501
Rong WuDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-4506-3764
Gopinath KrishnanRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Fen-Biao GaoRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Bin WuDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-9442-3041
Shuying SunDepartment of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8449-7370
Funding
PROGRAM IN MOLECULAR BIOPHYSICST32GM008403 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BARRICK, DOUGLAS E. · 1990 to 2019
$13.5MSingle molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTDRF1NS113820 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING, WU, BIN · 2020 to 2025
$6.2MInvestigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3MUnderstanding Frontotemporal Dementia Using Drosophila and iPSC ModelsRF1NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2022 to 2022
$2.1MThe role of m6A RNA methylation in C9ORF72-ALS/FTDRF1NS127925 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2022 to 2024
$2.0MMolecular mechanism of dipeptide repeat protein production from hexanucleotide repeats in C9ORF72-related ALS and FTDR01NS107347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2018 to 2022
$1.8MDysregulation of inhibitory synapse by poly-GR in C9ORF72-ALS/FTDR21AG072078 · NIA · JOHNS HOPKINS UNIVERSITY · PI SUN, SHUYING · 2021 to 2021
$450kNIA NIH HHS R21 AG072078NIGMS NIH HHS T32 GM008403NINDS NIH HHS R01 NS107347NINDS NIH HHS R37 NS057553NINDS NIH HHS RF1 NS101986NINDS NIH HHS RF1 NS113820NINDS NIH HHS RF1 NS127925
Abstract
Hexanucleotide repeat expansion in the
Indexed as
Amyotrophic Lateral SclerosisC9orf72 ProteinDNA Repeat ExpansionFrontotemporal DementiaInduced Pluripotent Stem CellsNeuronsHumansp38 Mitogen-Activated Protein KinasesPeptide Chain Elongation, TranslationalRibosomesStress, PhysiologicalC9orf72 ProteinC9orf72 protein, humanp38 Mitogen-Activated Protein Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.