ArticlePloS one2024
Impact of body mass index on mortality outcomes in intensive care patients with Staphylococcus aureus sepsis: A retrospective analysis.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Long-term metabolic-adiposity burden and cardiovascular risk: the cumTyG-WHtR in Chinese adults.BMC cardiovascular disorders · 2026Article
- Development and validation of a prognostic model incorporating the blood urea nitrogen-to-albumin ratio for predicting mortality in methicillin-resistant Staphylococcus aureus bloodstream infection.BMC infectious diseases · 2026Article
- Stress hyperglycemia ratio and short-term mortality in critically ill septic patients: stratified analysis by diabetes status.BMC infectious diseases · 2026Article
- Advanced lung cancer inflammation index and all-cause mortality in critically ill patients with sepsis: analysis of the MIMIC-IV database.BMC infectious diseases · 2025Observational
- Associations between triglyceride-glucose body mass index and all-cause mortality in ICU patients with sepsis and acute heart failure.BMC cardiovascular disorders · 2025Article
- Association of PIV value with early mortality in ICU patients with sepsis-associated acute kidney injury from the MIMIC IV database.Scientific reports · 2025Article
- Association of body mass index changes with short-term mortality risks in ICU patients with sepsis across different admission BMI states: analysis of the MIMIC-IV database.Frontiers in immunology · 2025Article
- L-shaped association between triglyceride-glucose body mass index and short-term mortality in ICU patients with sepsis-associated acute kidney injury.Frontiers in medicine · 2024Article
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Abstract
backgroundEvidence associating body mass index (BMI) with the prognosis of Staphylococcus aureus sepsis remains scarce.
objectiveTo explore the association between BMI and clinical outcomes in intensive care units patients with Staphylococcus aureus sepsis.
methodsA retrospective analysis of patients with Staphylococcus aureus sepsis was conducted using the MIMIC-IV database from the Critical Care Medicine Information. Data were collected within the first 24 hours of intensive care units admission. The primary endpoint was 28-day mortality. The association between BMI and 28-day all-cause mortality was assessed using multivariable logistic regression, subgroup analyses, restricted cubic spline curves and Kaplan-Meier survival analysis.
resultsThe study included 2,295 patients with an average age of 63.5 (16.1) years, 60.2% of whom were male. Multivariate analysis revealed that each 1 kg/m2 increase in BMI was linked to a 2.8% decrease in the risk of 28-day mortality (adjusted OR = 0.972, 95% CI: 0.955-0.990, P = 0.002). Patients in the medium and high BMI categories had significantly lower risks of 28-day mortality compared to those in the low BMI group (OR [95% CI] 0.650 [0.474-0.891]; OR [95% CI] 0.516 [0.378-0.705]; P trend < 0.0001). The RCS model showed a non-linear association between BMI and 28-day mortality (P = 0.014). Kaplan-Meier analysis showed that patients with elevated BMI had lower 28-day mortality (P < 0.0001). Notably, significant interactions between AKI and SOFA with BMI were observed (P<0.05).
conclusionIncreased BMI is associated with a reduced risk of 28-day all-cause mortality in patients with Staphylococcus aureus sepsis.
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