Evidence map›Paper›PMID 39106169›Full record

Trial reportClinical oral implants research2024

A 3D micro-CT assessment of composition and structure of bone tissue after vertical and horizontal alveolar ridge augmentation using CAD/CAM-customized titanium mesh.

Alessandro Cucchi, Gregorio Marchiori, Maria Sartori, Milena Fini, Antonino Fiorino, Raffaele Donati, Giuseppe Corinaldesi, Melania Maglio

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Clinical oral implants research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Frontiers in bioengineering and biotechnology · 2026
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alessandro CucchiPrivate Practice, Bologna, Italy.ORCID 0000-0001-5155-2807
Gregorio MarchioriSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.ORCID 0000-0002-2171-1851
Maria SartoriSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Milena FiniScientific Direction, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Antonino FiorinoDepartment of Neuroscience, Reproductive Sciences and Dentistry, Federico II University of Naples, Naples, Italy.
Raffaele DonatiPrivate Practice, Lucca, Italy.
Giuseppe CorinaldesiSection of Oral Science, Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.
Melania MaglioSurgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo date, no studies have exploited micro-CT in humans to evaluate bone morphology and structure after bone augmentation with CAD/CAM-customized titanium mesh, in mandible and maxilla. The aim of this study was to assess the composition and microstructure of bone biopsy through micro-CT analysis. MATERIALS AND

methodsBone augmentation at both maxillary and mandible sites was performed on 30 patients randomly treated with customized mesh, either alone (M-) or covered with resorbable membrane (M+), in both cases filled 50:50 with autogenous bone and xenograft. After 6 months, biopsies were taken and micro-CT was performed on consecutive 1-mm-thick VOIs from coronal to apical side, measuring tissue volumes, trabecular thickness, spacing, and number.

resultsIn both groups, irrespective of membrane use, bone tissue (M-: 29.76% vs. M+: 30.84%) and residual graft material (M-: 14.87% vs. M+: 13.11%) values were similar. Differences were site-related (maxillary vs. mandibular) with higher percentage of bone tissue and trabecular density of low-mineralized bone and overall bone in the mandible.

conclusionsThe composition and structure of bone tissue, as assessed by micro-CT after alveolar ridge augmentation using CAD/CAM-customized titanium meshes, showed similar features regardless of whether a collagen membrane was applied.

Indexed as

Alveolar Ridge AugmentationComputer-Aided DesignSurgical MeshTitaniumX-Ray MicrotomographyAdultAgedBone TransplantationFemaleHumansImaging, Three-DimensionalMaleMandibleMaxillaMiddle AgedTitaniumbone biopsiesbone regenerationCAD/CAM meshmicro‐CTrandomized clinical trialresorbable membrane

Identifiers

PMID39106169
PMCPMC11629439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.