Evidence map›Paper›PMID 39106117›Full record

ArticleInternational braz j urol : official journal of the Brazilian Society of Urology

Transperineal versus Transrectal MRI/TRUS fusion-guided prostate biopsy in a large, ethnically diverse, and multiracial cohort.

Lorenzo Storino Ramacciotti, David Strauss, Francesco Cei, Masatomo Kaneko, Daniel Mokhtar, Jie Cai, Delara Jadvar, Giovanni E Cacciamani, Manju Aron, Pierre B Halteh and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. MRI Changed the diagnosis of prostate cancer.International braz j urol : official journal of the Brazilian Society of Urology
    Article
  7. Prostate Biopsy Once Again Is a Hot Topic in This Issue of the International Brazilian Journal of Urology.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lorenzo Storino RamacciottiUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
David StraussUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Francesco CeiUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Masatomo KanekoUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Daniel MokhtarUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jie CaiUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Delara JadvarUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Giovanni E CacciamaniUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Manju AronUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Pierre B HaltehDepartment of Radiology Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Vinay DuddalwarUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Inderbir GillUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Andre Luis AbreuUSC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare transperineal (TP) vs transrectal (TR) magnetic resonance imaging (MRI) and transrectal ultrasound (TRUS) fusion-guided prostate biopsy (PBx) in a large, ethnically diverse and multiracial cohort. MATERIALS AND

methodsConsecutive patients who underwent multiparametric (mp) MRI followed by TP or TR TRUS-fusion guided PBx, were identified from a prospective database (IRB #HS-13-00663). All patients underwent mpMRI followed by 12-14 core systematic PBx. A minimum of two additional target-biopsy cores were taken per PIRADS≥3 lesion. The endpoint was the detection of clinically significant prostate cancer (CSPCa; Grade Group, GG≥2). Statistical significance was defined as p<0.05.

resultsA total of 1491 patients met inclusion criteria, with 480 undergoing TP and 1011 TR PBx. Overall, 11% of patients were Asians, 5% African Americans, 14% Hispanic, 14% Others, and 56% White, similar between TP and TR (p=0.4). For PIRADS 3-5, the TP PBx CSPCa detection was significantly higher (61% vs 54%, p=0.03) than TR PBx, but not for PIRADS 1-2 (13% vs 13%, p=1.0). After adjusting for confounders on multivariable analysis, Black race, but not the PBx approach (TP vs TR), was an independent predictor of CSPCa detection. The median maximum cancer core length (11 vs 8mm; p<0.001) and percent (80% vs 60%; p<0.001) were greater for TP PBx even after adjusting for confounders.

conclusionsIn a large and diverse cohort, Black race, but not the biopsy approach, was an independent predictor for CSPCa detection. TP and TR PBx yielded similar CSPCa detection rates; however the TP PBx was histologically more informative.

Indexed as

Image-Guided BiopsyProstateProstatic NeoplasmsUltrasonography, InterventionalAgedHumansMagnetic Resonance Imaging, InterventionalMaleMiddle AgedMultiparametric Magnetic Resonance ImagingNeoplasm GradingPerineumReproducibility of ResultsEthnicityProstatic NeoplasmsUltrasound, High-Intensity Focused, Transrectal

Identifiers

PMID39106117
PMCPMC11446557

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.