ReviewExperimental physiology2024
Mitigating disuse-induced skeletal muscle atrophy in ageing: Resistance exercise as a critical countermeasure.
Review in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Trends and frontiers in disuse muscle atrophy research.Frontiers in public health · 2025Pooled it
- A Scoping Review on Bone Mass Status in Individuals with Transfemoral Amputation.Journal of prosthetics and orthotics : JPO · 2026Review
- Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10-day bed rest in older adults.The Journal of physiology · 2026Article
- Mitochondria-sarcoplasmic reticulum crosstalk as a modulator of skeletal muscle mass.Journal of physiology and biochemistry · 2026Review
- Pre-operative fear of falling is associated with worse 3-year mobility and quality of life in elderly hip fracture patients: a post-hoc analysis of a prospective cohort.Journal of orthopaedic surgery and research · 2026Article
- Neuromodulation strategies in postburn care for pain rehabilitation and scar remodelling.Communications medicine · 2026Review
- Review
- Investigating the utility of sarcopenia associated SARC-F and MSRA questionnaires in identifying falls and self-reported functional impairment in juvenile idiopathic arthritis.Pediatric rheumatology online journal · 2026Article
- Ribosome Biogenesis and Translational Control in Skeletal Muscle Atrophy and Hypertrophy: Mechanisms and Therapeutic Perspectives.Biomolecules · 2026Review
- Body Composition's Association with Resting Energy Expenditure Prediction in a Large Population Sample from Different Age Groups, Sex, and Physical Activity Levels.Journal of functional morphology and kinesiology · 2026Article
- Neuromuscular Mechanisms and Oxidative Stress in Skeletal Muscle Atrophy: Emerging Stem Cell and Gene-Based Therapeutic Strategies.Muscles (Basel, Switzerland) · 2026Review
- Functional training for sarcopenia in older adults: mechanisms, benefits, and clinical implications.Frontiers in public health · 2026Review
- Resistance Exercise Counteracts Skeletal Muscle Atrophy in T2DM Mice by Upregulating FGF21 and Activating PI3K/Akt Pathway.Biomolecules · 2025Article
- Protein-based perioperative nutrition interventions for improving muscle mass and functional outcomes following orthopaedic surgery.Experimental physiology · 2025Review
- Cell biomechanics on muscle atrophy: from intricate mechanisms to therapeutic frontiers.Annals of medicine · 2025Review
- Muscle preservation during hospitalization: energy balance, protein intake, and habitual physical activity.Current opinion in clinical nutrition and metabolic care · 2025Review
- The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis.Experimental physiology · 2025Review
- Mechanical Stimulation in the Residual Femur During Gait in Transfemoral Prosthesis Users Provides a Potential Reason for Bone Mineral Density Loss.International journal for numerical methods in biomedical engineering · 2025Article
- Anti-Atrophic Effects of Dichotomine B fromMolecules (Basel, Switzerland) · 2025Article
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The gradual deterioration of physiological systems with ageing makes it difficult to maintain skeletal muscle mass (sarcopenia), at least partly due to the presence of 'anabolic resistance', resulting in muscle loss. Sarcopenia can be transiently but markedly accelerated through periods of muscle disuse-induced (i.e., unloading) atrophy due to reduced physical activity, sickness, immobilisation or hospitalisation. Periods of disuse are detrimental to older adults' overall quality of life and substantially increase their risk of falls, physical and social dependence, and early mortality. Disuse events induce skeletal muscle atrophy through various mechanisms, including anabolic resistance, inflammation, disturbed proteostasis and mitochondrial dysfunction, all of which tip the scales in favour of a negative net protein balance and subsequent muscle loss. Concerningly, recovery from disuse atrophy is more difficult for older adults than their younger counterparts. Resistance training (RT) is a potent anabolic stimulus that can robustly stimulate muscle protein synthesis and mitigate muscle losses in older adults when implemented before, during and following unloading. RT may take the form of traditional weightlifting-focused RT, bodyweight training and lower- and higher-load RT. When combined with sufficient dietary protein, RT can accelerate older adults' recovery from a disuse event, mitigate frailty and improve mobility; however, few older adults regularly participate in RT. A feasible and practical approach to improving the accessibility and acceptability of RT is through the use of resistance bands. Moving forward, RT must be prescribed to older adults to mitigate the negative consequences of disuse atrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.