Evidence map›Paper›PMID 39105989›Full record

ArticleCurrent microbiology2024

Poly I: C Alleviated Duck Intestinal Injury Infected with Duck Viral Enteritis by Inhibiting Apoptosis.

Yangzi Zhang, Yutong Wu, Xiaoke Zhang, Xuan Wang, Ling Pu, Jinge Xu, Zhengchang Wen, Ming Wen

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Polyinosinic-polycytidylic acid modulatesJournal of dental sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yangzi Zhang *The Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Yutong Wu *The Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Xiaoke ZhangThe Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Xuan WangThe Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Ling PuThe Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Jinge XuThe Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China.
Zhengchang WenThe Blight of Livestock and Poultry Research Laboratory, Institute of Animal Husbandry and Veterinary Medicine of Guizhou Academy of Agricultural Sciences, No. 1, Laolipo Nanming District, Guiyang, 550025, Guizhou, China. 911135914@qq.com.
Ming WenCollege of Animal Science, Guizhou University, Guiyang, Guizhou, China. as.mwen@gzu.edu.cn.

Funding

China Agriculture Research System of MOF and MARA CARS-42-53Guizhou Province Science and Technology Plan Project QKH[2020]1Y042Guizhou Province Science and Technology Plan Project QKH[2020]1Y137Guizhou Province Science and Technology Plan Project QKH[2022]005Guizhou Provincial Ecological Poultry Industry Technology System Feed and Nutrition Function Laboratory QKH [2017]-01National key research and development plan project 2022YFD1601701
6 · The paper itself

Abstract

Duck enteritis virus (DEV) may lead to vascular injury, gastrointestinal mucosal erosion, lymphoid organ injury, and Polyinosinic-polycytidylic acid (Poly I:C) has an antiviral effect by inducing low levels of interferon. The purpose of this study was to explore the pathogenesis of DEV-induced intestinal injury in ducks and to verify the therapeutic effects of different concentrations of Poly I:C. In this study, duck enteritis model was established by infecting healthy Pekin ducks with DEV. Duck intestinal tissues were extracted from normal control group, model group, and treatment group with different doses of Poly I:C. In vivo, HE and TUNEL staining were used to observe the morphological changes and apoptosis. In vitro, the proliferation and apoptosis of duck intestinal epithelial cells were evaluated by MTT assay, TUNEL staining, and flow cytometry. The results showed that Poly I:C protected ducks from DEV toxicity by improving intestinal morphology and inhibiting apoptosis. In addition, the antiviral effect of Poly I:C on DEV was found in a dose-dependent manner, with a more relatively obvious effect at a high dose of Poly I:C. All in all, these results demonstrated that Poly I:C played a vital role in the apoptosis induced by DEV in ducks and modest dose of Poly I:C treatment worked well and may provide important reference for the development of new antiviral drugs in the future.

Indexed as

ApoptosisDucksEnteritisPoly I-CAnimalsAntiviral AgentsIntestinal MucosaIntestinesMardivirusPoultry DiseasesAntiviral AgentsPoly I-C

Identifiers

PMID39105989

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.