Evidence map›Paper›PMID 39105973›Full record

ArticleMetabolic brain disease2024

Diosmin ameliorates inflammation, apoptosis and activates PI3K/AKT pathway in Alzheimer's disease rats.

Yanbo Wang, Xiaojun Ye, Wenwen Su, Ci Yan, Haiyan Pan, Xiaowei Wang, Sen Shao

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Natural Molecules for Brain Health and Resilience.International journal of molecular sciences · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanbo WangDepartment of Neurology, the Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310000, China.
Xiaojun YeDepartment of Neurology, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang, 310015, China.
Wenwen SuDepartment of Internal Medicine, CiXi Seventh People's Hospital, Ningbo, Zhejiang, 315000, China.
Ci YanDepartments of Psychiatry, Affiliated Mental Health Center, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310000, China.
Haiyan PanDepartment of Endocrinology, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310000, China.
Xiaowei WangDepartment of Respiratory Medicine, The Third Affiliated Hospital of Zhejiang Chinese Medicine University, Hangzhou, Zhejiang, 310000, China.
Sen ShaoDepartment of Neurology, Xixi Hospital of Hangzhou Affiliated to Zhejiang University School of Medicine, No. 2, Hengbu Street, Hangzhou, Zhejiang, 310023, China. hzsxxyy2015@sohu.com.

Funding

Zhejiang Medical and Health Science and Technology Plan Project 2022KY1025
6 · The paper itself

Abstract

Alzheimer's disease (AD), a prevalent cognitive disorder among the elderly, is frequently linked to the abnormal accumulation of myloid-β (Aβ), which is mainly as a result of neuronal death and inflammation. Diosmin, a flavonoid, is considered a potential drug for the treatment of AD. Our study aimed to uncover the molecular mechanism of diosmin in AD therapy. Here, rats were randomly divided into three groups: control, Aβ

Indexed as

Alzheimer DiseaseApoptosisDiosminInflammationPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRats, Sprague-DawleySignal TransductionAmyloid beta-PeptidesAnimalsDisease Models, AnimalHippocampusMaleNeuroprotective AgentsPeptide FragmentsRatsAmyloid beta-Peptidesamyloid beta-protein (25-35)DiosminNeuroprotective AgentsPeptide FragmentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAlzheimer’s diseaseamyloid-βDiosminPI3K/AKT signaling pathway

Identifiers

PMID39105973

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.