ArticleMagma (New York, N.Y.)2024
Parameter optimization for proton density fat fraction quantification in skeletal muscle tissue at 7 T.
Article in Magma (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Quantitative Susceptibility Mapping of Kidney Stones: An Ex Vivo MRI Phantom Study.Magnetic resonance in medicine · 2026Article
- Fat/Water Separation at 7 T Using a 3D Radial Sequence With Quasi-Continuous Echo Times.Magnetic resonance in medicine · 2026Article
- Multi-Parametric MRI Approach at 3 T and 7 T for Assessing Skeletal Muscle Pathology in Myofibrillar Myopathies: A Pilot Study.Journal of cachexia, sarcopenia and muscle · 2026Article
- Review of the Pathology of Muscle in Amyotrophic Lateral Sclerosis.International journal of molecular sciences · 2026Review
- Determination of Tissue Potassium and Sodium Concentrations in Dystrophic Skeletal Muscle Tissue Using Combined Potassium (NMR in biomedicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectiveTo establish an image acquisition and post-processing workflow for the determination of the proton density fat fraction (PDFF) in calf muscle tissue at 7 T. MATERIALS AND
methodsEcho times (TEs) of the applied vendor-provided multi-echo gradient echo sequence were optimized based on simulations of the effective number of signal averages (NSA*). The resulting parameters were validated by measurements in phantom and in healthy calf muscle tissue (n = 12). Additionally, methods to reduce phase errors arising at 7 T were evaluated. Finally, PDFF values measured at 7 T in calf muscle tissue of healthy subjects (n = 9) and patients with fatty replacement of muscle tissue (n = 3) were compared to 3 T results.
resultsSimulations, phantom and in vivo measurements showed the importance of using optimized TEs for the fat-water separation at 7 T. Fat-water swaps could be mitigated using a phase demodulation with an additional B
conclusionPDFF determination in calf muscle tissue is feasible at 7 T using a chemical shift-based approach with optimized acquisition and post-processing parameters.
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