Evidence map›Paper›PMID 39105913›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2024

Cardiac Progenitor Cell Metabolism.

Sadia Mohsin, Mohsin Khan

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sadia MohsinAging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Mohsin KhanCenter for Metabolic Disease Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA. mohsin.khan@temple.edu.

Funding

Enhancement of Cardiac Cell therapy by reintroduction of developmental signalingR01HL135117 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KHAN, MOHSIN · 2017 to 2021
$1.9M
Paracrine Modulation of Cardiac Repair processes by Cortical Bone Derived Stem CellsR01HL137850 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI MOHSIN, SADIA · 2018 to 2021
$1.6M
American Heart Association 20TPA35490355NHLBI NIH HHS R01 HL135117NHLBI NIH HHS R01 HL137850
6 · The paper itself

Abstract

Metabolism has emerged recently as an important determinant of stem cell function. Changes in metabolic signaling pathways precede changes in stem cell molecular and functional response. Pluripotent stem cells are highly proliferative and known to exhibit increased glycolysis. Similarly, adult stem cells reside in tissue niches in a quiescent state operating via glycolysis. Upon activation, adult stem cell metabolism transitions from glycolysis to oxidative phosphorylation which coincides with reduced proliferation and multilineage potential. In the heart, different populations of cardiac progenitor cells (CPCs) have been identified. CPCs regenerative potential is linked to changes in metabolic characteristics of cells, impacting cardiac repair following injury. Here, we discuss the methodologies for isolation and characterization of a novel cardiac progenitor cell population from the heart including measurement its metabolic features.

Indexed as

Stem CellsAnimalsCell DifferentiationCell ProliferationCell SeparationGlycolysisHumansMiceMyocardiumMyocytes, CardiacOxidative PhosphorylationCardiac progenitor cellsHeartMetabolismStem cells

Identifiers

PMID39105913

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.