Evidence map›Paper›PMID 39105842›Full record

ArticleArchives of orthopaedic and trauma surgery2024

Bone turnover markers in the preoperative assessment of bone quality - A prospective investigation of bone microstructure and advanced glycation endproducts in lumbar fusion patients.

Henryk Haffer, Maximilian Muellner, Erika Chiapparelli, Jiaqi Zhu, Yi Xin Han, Eve Donnelly, Jennifer Shue, Alexander P Hughes

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Article in Archives of orthopaedic and trauma surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Henryk HafferDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA.
Maximilian MuellnerDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA.
Erika ChiapparelliDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA.
Jiaqi ZhuDepartment of Epidemiology and Biostatistics, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA.
Yi Xin HanDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Eve DonnellyDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY, USA.
Jennifer ShueDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA.
Alexander P HughesDepartment of Orthopaedic Surgery, Hospital for Special Surgery, Weill Cornell Medicine, New York City, NY, USA. hughesa@hss.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEffective tools to evaluate bone quality preoperatively are scarce and the standard method to determine bone quality requires an invasive biopsy. A non-invasive, and preoperatively available method for bone quality assessment would be of clinical value. The purpose of this study is to investigate the associations of bone formation marker, serum bone alkaline phosphatase (BAP), and bone resorption marker, urine collagen cross-linked N-telopeptide (uNTX) to volumetric bone mineral density (vBMD), fluorescent advanced glycation endproducts (fAGEs) and bone microstructure. MATERIALS AND

methodsA cross-secional analysis using prospective data of patients undergoing lumbar spinal fusion was performed. BAP and uNTX were preoperatively collected. Quantitative computed tomography (QCT) was performed at the lumbar spine (vBMD ≤ 120 mg/cm

results127 prospectively enrolled patients (50.4% female, 62.5 years, BMI 28.7 kg/m

conclusionThis study demonstrated an inverse association of bone turnover markers and fAGEs. Both uNTX and BAP could not predict osteopenia/osteoporosis in the spine. uNTX reflects collagen characteristics and might have a complementary role to vBMD, as a non-invasive tool for bone quality assessment in spine surgery.

Indexed as

BiomarkersBone DensityBone RemodelingGlycation End Products, AdvancedLumbar VertebraeSpinal FusionAgedAlkaline PhosphataseBone Diseases, MetabolicCollagen Type ICross-Sectional StudiesFemaleHumansMaleMiddle AgedOsteoporosisAlkaline PhosphataseBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptideGlycation End Products, AdvancedPeptidesConnective tissueMultiphoton microscopyNon-enzymatic collagen cross-linkingQuantitative computed tomographyVolumetric bone mineral density

Identifiers

PMID39105842

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.