Evidence map›Paper›PMID 39105829›Full record

ArticleMolecular biology reports2024

Relationship between rs1410996 polymorphism of CFH gene and essential hypertension patients of Han from Yunnan Province.

Chengzhen Zhu, Li Guo, Yong Yuan, Hao Guo

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Chengzhen ZhuDepartment of Cardiovascular Medicine, Yancheng No.1 People's Hospital, Affiliated Hospital of Medical School, Nanjing University, Yancheng, China.
Li GuoDepartment of Radiology, 2nd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Yong YuanDepartment of emergency, 2nd Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Hao GuoDepartment of Cardiology, 1st Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. guohao677@163.com.

Funding

Yunnan Provincial Reserve Training Program for Young and Middle-aged Academic and Technical Leaders 202005AC160053
6 · The paper itself

Abstract

objectiveTo explore the relationship between rs1410996 polymorphism of CFH gene and essential hypertension (EH) in the Yunnan Han population.

methodsrs1410996 of CFH gene was genotyped based on the collected clinical phenotypes of the EH patients (n = 520) and healthy people (n = 494).

resultsOn the genotype model and dominance model, there was no relationship between rs1410996 of CFH gene and EH after adjustment (P > 0.05). On the dominance model of male EH patients, the pulse pressure (PP) level of CC genotype carriers was higher than that of (CT + TT) genotype carriers after adjustment (P < 0.05).

conclusionrs1410996 of CFH gene has no correlation with the genetic susceptibility to EH in the Yunnan Han population, but it is related to the PP level in male patients.

Indexed as

Complement Factor HEssential HypertensionGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAgedAllelesBlood PressureCase-Control StudiesChinaEast Asian PeopleFemaleGene FrequencyGenetic Association StudiesGenotypeHumansCFH protein, humanComplement Factor HCFH geneEssential hypertensionGene polymorphismPulse pressurers1410996

Identifiers

PMID39105829

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