Evidence map›Paper›PMID 39105662›Full record

ArticleJournal of magnetic resonance imaging : JMRI2025

Effect of Ethanol on Brain Electrical Tissue Conductivity in Social Drinkers.

Jun Cao, Iain K Ball, Elizabeth Summerell, Peter Humburg, Tom Denson, Caroline D Rae

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jun CaoNeuroscience Research Australia, Sydney, New South Wales, Australia.
Iain K BallPhilips Australia & New Zealand, North Ryde, New South Wales, Australia.
Elizabeth SummerellSchool of Psychology, The University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-4068-7703
Peter HumburgMark Wainwright Analytical Centre, Stats Central, The University of New South Wales, Sydney, New South Wales, Australia.
Tom DensonSchool of Psychology, The University of New South Wales, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-9620-4280
Caroline D RaeNeuroscience Research Australia, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-0673-8084

Funding

Australian Research Council DP200101845UNSW Medicine Neuroscience, Mental Health and Addictions Theme and SPHERE Mindgardens Clinical Academic Group
6 · The paper itself

Abstract

backgroundHow the biophysics of electrical conductivity measures relate to brain activity is poorly understood. The sedative, ethanol, reduces metabolic activity but its impact on brain electrical conductivity is unknown. PURPOSE: To investigate whether ethanol reduces brain electrical tissue conductivity. STUDY TYPE: Prospective. SUBJECTS: Fifty-two healthy volunteers (aged 18-37 years, 22 females, 30 males). FIELD STRENGTH/SEQUENCE: 3 T, T1-weighted, multi-shot, turbo-field echo (TFE); 3D balanced fast-field echo (bFFE). ASSESSMENT: Brain gray and white matter tissue conductivity measured with phase-based magnetic resonance electrical properties tomography (MREPT) compared before and 20 minutes after ethanol consumption (0.7 g/kg body weight). Differential conductivity whole brain maps were generated for three subgroups: those with strong ( STATISTICAL TESTS: Average breath alcohol levels were compared to the differential conductivity maps using linear regression. T-maps were generated (threshold P < 0.05 and P < 0.001; minimum cluster 48 mm

resultsWhole-group analysis showed decreased conductivity that did not survive statistical thresholding. Strong responders (N = 33) showed a consistent pattern of significantly decreased conductivity ( DATA

conclusionEthanol reduces brain tissue conductivity in a participant-dependent and spatially dependent fashion. EVIDENCE LEVEL: 1 TECHNICAL EFFICACY: Stage 2.

Indexed as

Alcohol DrinkingBrainEthanolAdolescentAdultBrain MappingElectric ConductivityFemaleGray MatterHumansMagnetic Resonance ImagingMaleProspective StudiesWhite MatterYoung AdultEthanolalcoholbrain activityelectrical properties tomography

Identifiers

PMID39105662
PMCPMC11803702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.