Evidence map›Paper›PMID 39105638›Full record

ArticleRadiology2024

Reliability of CT Enterography for Describing Fibrostenosing Crohn Disease.

Florian Rieder, Christopher Ma, Jurij Hanzel, Joel G Fletcher, Mark E Baker, Zhongya Wang, Leonardo Guizzetti, Lisa M Shackelton, Julie Rémillard, Mihir Patel and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Crohn Disease Strictures: Multimodality Imaging to Identify Imaging Biomarkers.Radiographics : a review publication of the Radiological Society of North America, Inc · 2025
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Anti-fibrotics in inflammatory bowel diseases: Challenges and successes.Advances in pharmacology (San Diego, Calif.) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Florian Rieder *From the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-9087-1568
Christopher Ma *From the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
Jurij HanzelFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0003-3158-8014
Joel G FletcherFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-8941-5434
Mark E BakerFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0001-5023-3361
Zhongya WangFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-3866-8052
Leonardo GuizzettiFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0001-5864-8422
Lisa M ShackeltonFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-1788-475X
Julie RémillardFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
Mihir PatelFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0009-0002-5659-1340
Jiafei NiuFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
Ronald OttichiloFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
Cynthia S SantillanFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-1479-0950
Nunzia CapozziFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-1207-3069
Stuart A TaylorFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
David H BruiningFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0003-4320-8429
Guangyong ZouFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0001-5773-4185
Brian G FeaganFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-6914-3822
Vipul Jairath *From the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).
Jordi Rimola *From the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).ORCID 0000-0002-1814-4198
Stenosis Therapy and Anti-Fibrotic Research (STAR) ConsortiumFrom the Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (F.R.); Department of Gastroenterology, Hepatology, and Nutrition, Digestive Diseases and Surgery Institute and Program for Global Translational Inflammatory Bowel Diseases Research, Cleveland Clinic, Cleveland, Ohio (F.R., M.P., J.N., R.O.); Departments of Medicine and Community Health Sciences, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, Alberta, Canada (C.M.); Alimentiv, London, Ontario, Canada (C.M., J.H., Z.W., L.G., L.M.S., J. Rémillard, G.Z., B.G.F., V.J.); Department of Gastroenterology, University of Ljubljana, University Medical Centre Ljubljana, Ljubljana, Slovenia (J.H.); Department of Radiology, Mayo Clinic, Rochester, Minn (J.G.F.); Section of Abdominal Imaging, Imaging Institute, Digestive Diseases and Surgery Institute and Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio (M.E.B.); Department of Radiology, University of California San Diego, San Diego, Calif (C.S.S.); Department of Radiology, IBD Unit, Hospital Clínic de Barcelona, Barcelona, Spain (N.C., J. Rimola); Pediatric and Adult Cardiothoracic and Vascular, Oncohematologic and Emergency Radiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy (N.C.); Centre for Medical Imaging, University College London, London, England (S.A.T.); Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine and Science, Rochester, Minn (D.H.B.); and Departments of Medicine and Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada (B.G.F., V.J.).

Funding

Creeping fat and Crohn's disease associated stricturesR01DK123233 · NIDDK · CLEVELAND CLINIC LERNER COM-CWRU · PI RIEDER, FLORIAN · 2020 to 2024
$1.9M
NIDDK NIH HHS R01 DK123233
6 · The paper itself

Abstract

Background Standardized methods to measure and describe Crohn disease strictures at CT enterography are needed to guide clinical decision making and for use in therapeutic studies. Purpose To assess the reliability of CT enterography features to describe Crohn disease strictures and their correlation with stricture severity. Materials and Methods A retrospective study was conducted in 43 adult patients with symptomatic terminal ileal Crohn disease strictures who underwent standard-of-care CT enterography at a tertiary care center at the Cleveland Clinic between January 2008 and August 2016. After training on standardized definitions, four abdominal radiologists blinded to all patient information assessed imaging features (seven continuous measurements and nine observations) of the most distal ileal stricture in two separate sessions (separated by ≥2 weeks) in random order. Features with an interrater intraclass correlation coefficient (ICC) of 0.41 or greater (ie, moderate reliability or better) were considered reliable. Univariable and multivariable linear regression analysis identified reliable features associated with a visual analog scale of overall stricture severity. Significant reliable features were assessed as components of a CT enterography-based model to quantitate stricture severity. Results Examinations in 43 patients (mean age, 52 years ± 16 [SD]; 23 female) were evaluated. Five continuous measurements and six observations demonstrated at least moderate interrater reliability (interrater ICC range, 0.42 [95% CI: 0.25, 0.57] to 0.80 [95% CI: 0.67, 0.88]). Of these, 10 were univariably associated with stricture severity, and three continuous measurements-stricture length (interrater ICC, 0.64 [95% CI: 0.42, 0.81]), maximal associated small bowel dilation (interrater ICC, 0.80 [95% CI: 0.67, 0.88]), and maximal stricture wall thickness (interrater ICC, 0.50 [95% CI: 0.34, 0.62])-were independently associated (

Indexed as

Crohn DiseaseTomography, X-Ray ComputedAdultAgedConstriction, PathologicFemaleHumansMaleMiddle AgedReproducibility of ResultsRetrospective Studies

Identifiers

PMID39105638
PMCPMC11366669

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