Evidence map›Paper›PMID 39105632›Full record

ReviewFuture microbiology2024

Fighting fire with fire: using infectious agents to treat persistent infection.

Maha Albukhari, Maria Bagies, Tanya Lizbeth, Shyamasundaran Kottilil

Abstract readReview
In one paragraph

Review in Future microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maha AlbukhariDepartment of Internal Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.
Maria BagiesDepartment of Internal Medicine, University of Maryland Medical Center, Baltimore, MD 21201, USA.
Tanya LizbethKing's College, London, WC2R 2LS, UK.
Shyamasundaran KottililInstitute of Human Virology, University of Maryland Medical Center, Baltimore, MD 21201, USA.ORCID 0000-0001-7471-0812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infectious diseases lead to significant morbidity and mortality. Often, resolution of the acute stage of the disease leads to microbial persistence, resulting in chronic debilitating disease. Management of persistent infections frequently requires lifelong therapy with antimicrobial agents. These infections could be chronic viral infections like HIV, hepatitis B or chronic bacterial persistent infections like prosthetic joint infections caused by multi-drug resistant organisms. Bacteriophages have been designed specifically to target recalcitrant bacterial infections, such as prosthetic joint infections with varying success. In this review, we describe the historic evolution of scenarios and risks associated with innovative therapy using infectious agents to treat other persistent infections.

Indexed as

Bacterial InfectionsPhage TherapyVirus DiseasesAnimalsBacteriophagesDrug Resistance, MicrobialProsthesis-Related Infectionsbacteriophagesfunctional curehepatitis Bpersistencesporozoitessyphilis

Identifiers

PMID39105632
PMCPMC11529199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.