Evidence map›Paper›PMID 39105589›Full record

SynthesisThe journal of ECT2025

Prognostic Factors and Incidence for Postictal Agitation After Electroconvulsive Therapy: A Systematic Review and Meta-analysis.

Melissa Ertman, Emy S van der Valk Bouman, Pascal R D Clephas, Tom K Birkenhager, Markus Klimek

Registry-linked trialAbstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in The journal of ECT, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06817330 (the Effect of a MUsic Intervention on poStictal Agitation in Electroconvulsive Therapy Patients), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06817330 narecruitingnot on this map

the Effect of a MUsic Intervention on poStictal Agitation in Electroconvulsive Therapy Patients: the MUSE Trial

TypeinterventionalSponsorErasmus Medical CenterRan2025 to 2027Enrolled92ConditionsMusic Intervention, Electroconvulsive Therapy Treated Patients, Agitation on Recovery From SedationArmsIntervention group, listening to recorded music, Control group, headphones with no music
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Characteristics and outcomes of early-terminated acute electroconvulsive therapy courses: A retrospective cohort study.Dusunen adam : Bakirkoy Ruh ve Sinir Hastaliklari Hastanesi yayin organi · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melissa Ertman
Emy S van der Valk BoumanFrom the Departments of Neuroscience.
Pascal R D ClephasAnesthesiology.
Tom K BirkenhagerPsychiatry, Erasmus Medical Center, Rotterdam, the Netherlands.
Markus KlimekAnesthesiology.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractPostictal agitation (PIA) is an adverse effect of electroconvulsive therapy (ECT) and is known to predict other side effects of ECT, but inconsistencies in the literature remain regarding PIA prognostic factors and incidence. Therefore, a systematic review and meta-analysis were conducted (1) to identify prognostic factors for PIA following ECT and (2) to elucidate the diverse incidences of PIA following ECT based on demographic and clinical characteristics. Specifically, electronic databases were searched for retrospective observational studies and randomized controlled trials (RCTs) that objectively reported PIA incidence. Additional inclusion criteria encompassed studies involving patients 18 years or older and allowed for the extraction of PIA prognostic factors. This resulted in the inclusion of 21 articles with 66,047 patients in total. A total of 35 prognostic factors were identified for PIA after ECT, consisting of 8 anesthesia-related, 19 patient-related, and 8 ECT-related prognostic factors. A meta-analysis was conducted for 7 prognostic factors. None of the prognostic factors demonstrated a significant effect on reducing or increasing PIA incidence. Mean PIA was 13.9% (18.0% adjusted) at the patient level and 12.4% (16.5% adjusted) at the session level. Overall risk of bias was generally moderate to low, except in the outcome measurement domain, where 43% of the studies had a high risk of bias. Although none of the prognostic factors in meta-analysis were significant, several other prognostic factors consistently indicated increased or decreased risk, providing direction for future research. A scarcity of (high-quality) data emphasizes the need for additional research on this topic to be conducted.

Indexed as

Electroconvulsive TherapyPsychomotor AgitationSeizuresHumansIncidencePrognosis

Identifiers

PMID39105589
PMCPMC11895820

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.