Evidence map›Paper›PMID 39105476›Full record

ArticleEuropean journal of heart failure2024

Ventilation strategies in cardiogenic shock: Insights from the AltShock-2 registry.

Alice Sacco, Andrea Montisci, Giovanni Tavecchia, Simone Frea, Davide Bernasconi, Costanza N J Colombo, Stephanie Bertolin, Giovanna Viola, Luca Villanova, Martina Briani and 19 more

Abstract readMulticenter Study
In one paragraph

Article in European journal of heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Author Response: Efficacy of Noninvasive Ventilation Compared with Invasive Mechanical Ventilation in Cardiogenic Shock: A Systematic Review and Meta-analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  2. Efficacy of Non-invasive Ventilation Compared with Invasive Mechanical Ventilation in Cardiogenic Shock: A Systematic Review and Meta-analysis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  3. Noninvasive Ventilation in Cardiogenic Shock: Reconsidering Contraindications.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026
    Article
  4. Article
  5. Article
  6. Respiratory Support and Mortality Risk Across the Spectrum of Cardiogenic Shock Severity.Journal of the Society for Cardiovascular Angiography & Interventions · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Alice SaccoCardiac Intensive Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Andrea MontisciDivision of Cardiothoracic Intensive Care, ASST Spedali Civili, Brescia, Italy.
Giovanni TavecchiaCardiac Intensive Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Simone FreaIntensive Cardiac Care Unit, Città della Salute e della Scienza di Torino, Turin, Italy.
Davide BernasconiBicocca Bioinformatics Biostatistics and Bioimaging Centre - B4, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy and Functional Department for Higher Education, Research, and Development, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Costanza N J ColomboDepartment of Clinical-Surgical, Diagnostic and Paediatric Sciences University of Pavia, Pavia, Italy.
Stephanie BertolinCardiothoracic and Vascular Anesthesia and Intensive Care, AO SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Giovanna ViolaCardiac Intensive Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Luca VillanovaCardiac Intensive Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Martina BrianiHumanitas Research Hospital IRCCS Rozzano, Milan, Italy.
Lisa PatriniDepartment of Clinical-Surgical, Diagnostic and Paediatric Sciences University of Pavia, Pavia, Italy.
Pier Paolo BocchinoIntensive Cardiac Care Unit, Città della Salute e della Scienza di Torino, Turin, Italy.
Carlotta Sorini DiniDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Nicoletta D'EttoreCardiologia, Ospedale San Giacomo, Novi Ligure, Italy.
Maurizio BertainaDivision of Cardiology, San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.
Mario IannacconeDivision of Cardiology, San Giovanni Bosco Hospital, ASL Città di Torino, Turin, Italy.
Luciano PotenaCardiology Unit, Cardio-Thoraco-Vascular Department, University Hospital of Bologna, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Letizia BertoldiHumanitas Research Hospital IRCCS Rozzano, Milan, Italy.
Serafina ValenteDivision of Cardiology, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Rita CamporotondoCardiology Unit, Fondazione Policlinico San Matteo Hospital IRCCS, Pavia, Italy.
Marco MariniDepartment of Cardiovascular Sciences, Clinic of Cardiology, Ospedali Riuniti, Ancona, Italy.
Matteo PagnesiCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Marco MetraCardiology, ASST Spedali Civili, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Gaetano De FerrariIntensive Cardiac Care Unit, Città della Salute e della Scienza di Torino, Turin, Italy.
Fabrizio OlivaCardiac Intensive Care Unit, De Gasperis Cardio Center, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Nuccia MoriciIRCCS S. Maria Nascente - Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy.
Federico PappalardoKore University, Enna, Italy.
Guido TavazziDepartment of Clinical-Surgical, Diagnostic and Paediatric Sciences University of Pavia, Pavia, Italy.
on behalf of AltShock‐2 Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo describe the use and the relation to outcome of different ventilation strategies in a contemporary, large, prospective registry of cardiogenic shock patients. METHODS AND

resultsAmong 657 patients enrolled from March 2020 to November 2023, 198 (30.1%) received oxygen therapy (OT), 96 (14.6%) underwent non-invasive ventilation (NIV), and 363 (55.3%) underwent invasive mechanical ventilation (iMV). Patients in the iMV group were significantly younger compared to those in the NIV and OT groups (63 vs. 69 years, p < 0.001). There were no significant differences between groups regarding cardiovascular risk factors. Patients with SCAI B and C were more frequently treated with OT and NIV compared to iMV (65.1% and 65.4% vs. 42.6%, respectively, p > 0.001), while the opposite trend was observed in SCAI D patients (12% and 12.2% vs. 30.9%, respectively, p < 0.001). All-cause mortality at 24 h did not differ amongst the three groups. The 60-day mortality rates were 40.2% for the iMV group, 26% for the OT group, and 29.3% for the NIV group (p = 0.005), even after excluding patients with cardiac arrest at presentation. In the multivariate analysis including SCAI stages, NIV was not associated with worse mortality compared to iMV (hazard ratio 1.97, 95% confidence interval 0.85-4.56), even in more severe SCAI stages such as D.

conclusionsCompared to previous studies, we observed a rising trend in the utilization of NIV among cardiogenic shock patients, irrespective of aetiology and SCAI stages. In this clinical scenario, NIV emerges as a safe option for appropriately selected patients.

Indexed as

RegistriesRespiration, ArtificialShock, CardiogenicAgedFemaleHumansMaleMiddle AgedNoninvasive VentilationOxygen Inhalation TherapyProspective StudiesRisk FactorsSurvival RateCardiogenic shockInvasive mechanical ventilationMechanical ventilationNon‐invasive ventilationPositive pressure ventilation

Identifiers

PMID39105476
PMCPMC11659490

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.