Evidence map›Paper›PMID 39105443›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2025

Self-defined former smokers consume the highest opioid quantities following knee and shoulder arthroscopy.

Hassaan Abdel Khalik, Ajaykumar Shanmugaraj, Seper Ekhtiari, Nolan S Horner, Aaron Gazendam, Nicole Simunovic, Olufemi R Ayeni, NO PAin Investigators

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Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Self-defined former smokers consume the highest opioid quantities following knee and shoulder arthroscopy.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hassaan Abdel KhalikDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada.
Ajaykumar ShanmugarajUniversity of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada.
Seper EkhtiariDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada.
Nolan S HornerGenesis Orthopedics and Sports Medicine, Chicago, Illinois, USA.
Aaron GazendamDepartment of Surgery, Division of Orthopaedic Surgery, University of Toronto, Toronto, Ontario, Canada.
Nicole SimunovicDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada.
Olufemi R AyeniDepartment of Surgery, Division of Orthopaedics, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4219-8564
NO PAin Investigators

Funding

None
6 · The paper itself

Abstract

purposeTo identify risk factors associated with increased postoperative opioid consumption and inferior pain outcomes following knee and shoulder arthroscopy.

methodsUsing the data set from the NonOpioid Prescriptions after Arthroscopic Surgery in Canada (NO PAin) trial, eight prognostic factors were chosen a priori to evaluate their effect on opioid consumption and patient-reported pain following arthroscopic knee and shoulder surgery. The primary outcome was the number of oral morphine equivalents (OMEs) consumed at 2 and 6 weeks postoperatively. The secondary outcome was patient-reported postoperative pain using the Visual Analogue Scale (VAS) at 2 and 6 weeks postoperatively. A multivariable linear regression was used to analyse these outcomes with eight prognostic factors as independent variables.

resultsTobacco usage was significantly associated with higher opioid usage at 2 (p < 0.001) and 6 weeks (p = 0.02) postoperatively. Former tobacco users had a higher 2-week (p = 0.002) and cumulative OME (p = 0.002) consumption compared to current and nonsmokers. Patients with a higher number of comorbidities (p = 0.006) and those who were employed (p = 0.006) reported higher pain scores at 6 weeks. Patients in the 'not employed/other' category had significantly lower pain scores at 6 weeks postoperatively (p = 0.046).

conclusionFormer smoking status was significantly associated with increased post-operative opioid consumption following knee and shoulder arthroscopy at 2 and 6 weeks postoperatively. Increased pain was found to be significantly associated with employment status and an increasing number of comorbidities at 6 weeks postoperatively. These findings can aid clinicians in identifying and mitigating increased opioid utilization as well as worse pain outcomes in high-risk patient populations. LEVEL OF EVIDENCE: Level III, cohort study.

Indexed as

Analgesics, OpioidArthroscopyKnee JointPostoperative PainShoulder JointSmokingAdultCanadaFemaleHumansMaleMiddle AgedPain MeasurementRisk FactorsAnalgesics, Opioidknee arthroscopymultimodal analgesiaopioid consumptionpostoperative painshoulder arthroscopy

Identifiers

PMID39105443
PMCPMC11848975

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.