Trial reportJournal of travel medicine2024
Assessing Wolbachia-mediated sterility for dengue control: emulation of a cluster-randomized target trial in Singapore.
Trial report in Journal of travel medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Adjacent spillover efficacy of Wolbachia for control of dengue: emulation of a cluster randomised target trial.BMC medicine · 2025Trial
- Impact of Wolbachia-mediated incompatible and sterile insect techniques on dengue incidence: a large-scale cluster randomised controlled trial.EBioMedicine · 2026Article
- Insecticide resistance in larval populations of Aedes aegypti and Aedes albopictus from Panama.Tropical medicine and health · 2026Article
- EliminatingInsects · 2026Article
- Heterogeneous suppressive effect of Wolbachia incompatible insect technique coupled with sterile insect technique across time and historical Ae. aegypti abundance - using distributional synthetic controls.PLoS computational biology · 2026Article
- The inhibition mechanism ofFrontiers in microbiology · 2026Review
- Measuring real-time disease transmissibility with temperature-dependent generation intervals.PLoS computational biology · 2026Article
- Advances in male sex separation for the support of mosquito control programs.Frontiers in insect science · 2026Review
- Prevention and control of dengue and Aedes mosquitoes in South and Southeast Asia: Interventions, challenges, and future recommendations.Dialogues in health · 2025Review
- Enhanced mosquito sex separation using NaCl for optimised sterile insect technique and incompatible insect technique programmes.Scientific reports · 2025Article
- Spatiotemporal prevalence and characterization of the lineage I insect-specific flavivirus, Quang Binh virus, isolated fromThe Journal of general virology · 2025Article
- Review
- Influence of air pollution and climate variability on dengue in Singapore: a time-series analysis.Scientific reports · 2025Article
- ExploitingPathogens (Basel, Switzerland) · 2025Review
- Suppression of Aedes aegypti may not affect sympatric Aedes albopictus populations: findings from two years of entomological surveillance in Singapore.Scientific reports · 2025Article
- Review
- Assessing the direct and spillover protective effectiveness of Wolbachia-mediated introgression to combat dengue.EBioMedicine · 2024Article
- Wolbachia incompatible insect technique program optimization over large spatial scales using a process-based model of mosquito metapopulation dynamics.BMC biology · 2024Article
- Evaluating quasi-experimental approaches for estimating epidemiological efficacy of non-randomised field trials: applications in Wolbachia interventions for dengue.BMC medical research methodology · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
backgroundMatings between male Aedes aegypti mosquitoes infected with wAlbB strain of Wolbachia and wildtype females yield non-viable eggs. We evaluated the efficacy of releasing wAlbB-infected Ae. aegypti male mosquitoes to suppress dengue.
methodsWe specified the protocol of a two-arm cluster-randomized test-negative controlled trial (cRCT) and emulated it using a nationally representative test-negative/positive database of individuals reporting for febrile illness to any public hospital, general practitioner or polyclinic. We retrospectively built a cohort of individuals who reside in Wolbachia locations vs a comparator control group who do not reside in Wolbachia locations, using a nationally representative database of all individuals whom report for febrile illness and were tested for dengue at the Environmental Health Institute/hospital laboratories/commercial diagnostic laboratories, through general practitioner clinic, polyclinic or public/private hospital from epidemiological week (EW) 1 2019 to EW26 2022. We emulated a constrained randomization protocol used in cRCTs to balance dengue risk between intervention and control arms in the pre-intervention period. We used the inverse probability weighting approach to further balance the intervention and control groups using a battery of algorithmically selected sociodemographic, environmental and anthropogenic variables. Intention-to-treat analyses were conducted to estimate the risk reduction of dengue given Wolbachia exposure.
resultsIntention-to-treat analyses revealed that, compared with controls, Wolbachia releases for 3, 6 and ≥12 months was associated to 47% (95% confidence interval: 25-69%), 44% (33-77%) and 61% (38-78%) protective efficacy against dengue, respectively. When exposed to ≥12 months of Wolbachia releases, protective efficacies ranged from 49% (13-72%) to 77% (60-94%) across years. The proportion of virologically confirmed dengue cases was lower overall in the intervention arm. Protective efficacies were found across all years, age and sex subgroups, with higher durations of Wolbachia exposure associated to greater risk reductions of dengue.
conclusionResults demonstrated that Wolbachia-mediated sterility can strengthen dengue control in tropical cities, where dengue burden is the greatest.
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