ArticleFrontiers in endocrinology2024
Relationship between triglyceride-glucose index and cognitive function among community-dwelling older adults: a population-based cohort study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Metabolic dysfunction and insulin resistance across major dementias: A comprehensive narrative review of the TyG index as a predictive marker.Metabolism open · 2026Review
- Edentulism and incident hip fracture among middle-aged and older adults in China: evidence from the CHARLS.BMC public health · 2026Article
- Association of TyG index and obesity indicators with cognitive function: a cross - sectional study from Chinese health check-up centers.BMC endocrine disorders · 2026Article
- Association between the atherogenic index of plasma and cognitive impairment.Scientific reports · 2026Article
- Mediation by atherogenic index of plasma of the association between body roundness index and cognitive impairment in older Chinese people: an analysis using health check-up data.Frontiers in public health · 2026Article
- Association of triglyceride-glucose index (TyG) and a body shape index (ABSI) with cognitive decline and dementia risk.PloS one · 2026Article
- Predictive Value of the Triglyceride-Glucose-Frailty Index for Depression and Cognitive Function in Perimenopausal Women: Insights from CHARLS.International journal of women's health · 2026Article
- A multi-stage validation of the C-reactive protein-triglyceride-glucose index for predicting mild cognitive impairment: evidence from clinical and nationwide prospective cohorts.Frontiers in endocrinology · 2026Article
- Low serum triglycerides related to delayed neurocognitive recovery in geriatric oral and maxillofacial surgery patients: A prospective cohort study.Lipids in health and disease · 2025Article
- Article
- Machine learning-based risk prediction model for cognitive dysfunction in elderly individuals.PloS one · 2025Article
- Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study.Frontiers in public health · 2025Article
- Association between atherogenic index of plasma and cognitive impairment in middle-aged and older adults: results from CHARLS.Frontiers in aging neuroscience · 2025Article
- Nonlinear association between TyG-related Indices and motoric cognitive risk syndrome in depressive individuals: evidence from the CHARLS study.Frontiers in psychiatry · 2025Article
- Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors.Frontiers in nutrition · 2025Article
- The relationship between dyslipidemia and chronic liver disease, with the mediating role of depressive symptoms.Frontiers in public health · 2025Article
- Comparative study of insulin resistance surrogate indices to predict mild cognitive impairment among Chinese non-diabetic adults.Lipids in health and disease · 2024Article
- Nutritional status and triglyceride-glucose index influence delirium in elderly heart failure patients.Scientific reports · 2024Article
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: The global increase in the aging population presents considerable challenges, particularly regarding cognitive impairment, a major concern for public health. This study investigates the association between the triglyceride-glucose (TyG) index, a measure of insulin resistance, and the risk of cognitive impairment in the elderly. Methods: This prospective cohort study enrolled 2,959 participants aged 65 and above from the 2015 and 2020 waves of the China Health and Retirement Longitudinal Study (CHARLS). The analysis employed a logistic regression model to assess the correlation between the TyG index and cognitive impairment. Results: The study included 2,959 participants, with a mean age of 71.2 ± 5.4 years, 49.8% of whom were female. The follow-up in 2020 showed a decrease in average cognitive function scores from 8.63 ± 4.61 in 2015 to 6.86 ± 5.45. After adjusting for confounding factors, a significant association was observed between TyG index quartiles and cognitive impairment. Participants in the highest quartile (Q4) of baseline TyG had a higher risk of cognitive impairment compared to those in the lowest quartile (Q1) (odds ratio [OR]: 1.97, 95% confidence intervals [CI]: 1.28-2.62, P<0.001). Conclusion: The study highlights a significant connection between elevated TyG index levels and cognitive impairment among older adults in China. These findings suggest that targeted interventions to reduce the TyG index could mitigate cognitive impairment and potentially lower the incidence of dementia.
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