Evidence map›Paper›PMID 39104775›Full record

ArticleBioactive materials2024

Topical treatment of tyrosine kinase 2 inhibitor through borneol-embedded hydrogel: Evaluation for preventive, therapeutic, and Recurrent management of psoriasis.

Yuhsien Lai, Xuesong Wu, Zhuoyu Jiang, Yifei Fang, Xiuting Liu, Dan Hong, Yanyun Jiang, Guozhen Tan, Shiqi Tang, Siyao Lu and 6 more

Abstract read
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Role of the STAT3 Signaling Pathway in Cell Proliferation and Inflammation in Psoriasis and Approaches for Targeted Therapies: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuhsien LaiDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Xuesong WuDepartment of Dermatology, University of California-Davis, Sacramento, CA, 95817, USA.
Zhuoyu JiangDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Yifei FangSchool of Biomedical Engineering, Sun Yat-sen University, 518107, China.
Xiuting LiuDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Dan HongDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Yanyun JiangDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Guozhen TanDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Shiqi TangDepartment of Biochemistry and Molecular Medicine, University of California-Davis, Sacramento, CA, 95817, USA.
Siyao LuDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
David WeiDepartment of Dermatology, University of California-Davis, Sacramento, CA, 95817, USA.
Sam T HwangDepartment of Dermatology, University of California-Davis, Sacramento, CA, 95817, USA.
Kit S LamDepartment of Biochemistry and Molecular Medicine, University of California-Davis, Sacramento, CA, 95817, USA.
Liangchun WangDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.
Yanyu HuangDepartment of Biochemistry and Molecular Medicine, University of California-Davis, Sacramento, CA, 95817, USA.
Zhenrui ShiDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 510120, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis, an immune-mediated inflammatory skin disorder characterized by a chronically relapsing-remitting course, continues to be primarily managed through topical therapy. While oral administration of tyrosine kinase 2 inhibitors (TYK2i) stands as an effective approach for psoriasis treatment, the potential efficacy of topical application of TYK2i remains unexplored. Herein, the carbomer/alginic acid hydrogel is embedded with borneol (BO) as a new topical carrier of TYK2i for achieving enhanced transdermal permeation and anti-psoriasis efficacy. The hydrogel system,

Indexed as

BorneolPsoriasisTopical hydrogelTransdermal deliveryTyrosine kinase 2 inhibitor

Identifiers

PMID39104775
PMCPMC11298611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.