ArticleFrontiers in nutrition2024
Novel insights into causal associations of body mass index or height with pneumothorax: a two-sample Mendelian randomization study.
Article in Frontiers in nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Thoracic morphological characteristics of primary spontaneous pneumothorax patients requiring surgical intervention.Journal of thoracic disease · 2025Article
- Anthropometric thoracic measurements and smoking habits in patients with primary spontaneous pneumothorax: A case-control study.Annals of thoracic medicineArticle
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Authors and funding
5 authors.
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Abstract
Background: Observational studies have reported an association between body mass index (BMI) as well as height and the risk of pneumothorax. However, it has long been unclear whether BMI or height are causally associated with pneumothorax. Methods: Genetic summary data for BMI, height and pneumothorax were retrieved from multiple independent large genome-wide association studies (GWAS). A series of quality control steps were conducted to select instruments. Four independent two-sample Mendelian randomization (MR) analyzes were performed to adequately assess the causal relationship between BMI or height on pneumothorax, and the robustness of the results was assessed by a series of sensitivity analyzes. Results: Height increased the risk of pneumothorax with an OR of 1.5181 (95%CI 1.3092-1.7604; Conclusion: Our results supported a genetic association between height and pneumothorax. We found that height increased the risk of pneumothorax. However, no evidence was found to suggest a causal relationship between BMI and pneumothorax risk. The relationship between BMI and pneumothorax requires further in-depth analysis.
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