Evidence map›Paper›PMID 39104646›Full record

ArticleSkin health and disease2024

Severe atypical juvenile pityriasis rubra pilaris diagnosed in adulthood with a dramatic improvement with ustekinumab.

Rebecca L McCarthy, Jaimie Oldham, Elsa Barbosa, Catriona Sinclair, Malvina Cunningham, Edel A O'Toole

Abstract readCase Reports
In one paragraph

Article in Skin health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca L McCarthyFaculty of Medicine and Dentistry Centre for Cell Biology and Cutaneous Research Blizard Institute Queen Mary University of London London UK.ORCID https://orcid.org/0000-0002-7126-8384
Jaimie OldhamDepartment of Dermatology Royal London Hospital Barts Health NHS Trust London UK.ORCID https://orcid.org/0000-0002-9772-3218
Elsa BarbosaDepartment of Dermatology Royal London Hospital Barts Health NHS Trust London UK.
Catriona SinclairDepartment of Dermatology Broomfield Hospital Mid and South Essex NHS Foundation Trust Basildon UK.
Malvina CunninghamDepartment of Dermatology Royal London Hospital Barts Health NHS Trust London UK.
Edel A O'TooleFaculty of Medicine and Dentistry Centre for Cell Biology and Cutaneous Research Blizard Institute Queen Mary University of London London UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pityriasis rubra pilaris (PRP) is a rare skin disease which manifests as a psoriasiform dermatosis and palmoplantar keratoderma and has significant clinical-histopathological overlap with psoriasis. Recently, several case reports have demonstrated successful treatment of PRP with anti-IL7A and anti-IL12/anti-IL23 monoclonal antibodies. We report a case of atypical juvenile PRP definitively diagnosed during adulthood with presence of CARD14 mutation. This case demonstrates a dramatic improvement with ustekinumab and highlights the role of genetic testing in chronic disease of diagnostic uncertainty.

Identifiers

PMID39104646
PMCPMC11297448

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.