Evidence map›Paper›PMID 39104610›Full record

ArticleFrontiers in neuroscience2024

A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging.

Lucia Maccioni, Carranza Mellana Michelle, Ludovica Brusaferri, Erica Silvestri, Alessandra Bertoldo, Julia J Schubert, Maria A Nettis, Valeria Mondelli, Oliver Howes, Federico E Turkheimer and 5 more

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucia MaccioniDepartment of Information Engineering, University of Padova, Padova, Italy.
Carranza Mellana MichelleDepartment of Information Engineering, University of Padova, Padova, Italy.
Ludovica BrusaferriAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Erica SilvestriDepartment of Information Engineering, University of Padova, Padova, Italy.
Alessandra BertoldoDepartment of Information Engineering, University of Padova, Padova, Italy.
Julia J SchubertInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Maria A NettisInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Valeria MondelliInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Oliver HowesInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Federico E TurkheimerInstitute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
Michel BottlaenderBioMaps, Service Hospitalier Frédéric Joliot CEA, CNRS Inserm, Université Paris-Saclay, Orsay, France.
Benedetta BodiniParis Brain Institute, ICM, CNRS, Inserm, Sorbonne Université, Paris, France.
Bruno StankoffParis Brain Institute, ICM, CNRS, Inserm, Sorbonne Université, Paris, France.
Marco L LoggiaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States.
Mattia VeroneseDepartment of Information Engineering, University of Padova, Padova, Italy.

Funding

Imaging neuroglial mechanisms of neuropathic pain-opioid interaction in HIVR01DA047088 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO, RATAI, EVA-MARIA · 2018 to 2022
$4.3M
Evaluation of Cannabidiol for Reduction of Brain NeuroinflammationR01DA053316 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI GILMAN, JODI, LOGGIA, MARCO LUCIANO · 2021 to 2025
$3.9M
In-vivo imaging of spinal and brain glial activation in low back pain patientsR01NS095937 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5M
The Role of Brain Glial Activation in knee OstoarthritisR01NS094306 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI LOGGIA, MARCO LUCIANO · 2016 to 2020
$3.5M
NIDA NIH HHS R01 DA047088NIDA NIH HHS R01 DA053316NINDS NIH HHS R01 NS094306NINDS NIH HHS R01 NS095937
6 · The paper itself

Abstract

Introduction: Recent evidence suggests the blood-to-brain influx rate ( Methods: The method is tested on a multi-site dataset containing 177 Results: Comparison with standard kinetic methodology showed good-to-excellent intra-subject correlation for regional Discussion: This evidence supports

Indexed as

BBBIDIFkinetic modelingneuroinflammationPETTSPO

Identifiers

PMID39104610
PMCPMC11299498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.