Evidence map›Paper›PMID 39104523›Full record

ArticleFrontiers in immunology2024

Human liver derived mesenchymal stromal cells ameliorate murine ischemia-induced inflammation through macrophage polarization.

Yun Liang, Elif Ozdogan, Michael J Hansen, Hui Tang, Ishran Saadiq, Kyra L Jordan, James D Krier, Deep B Gandhi, Joseph P Grande, Lilach O Lerman and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Kratom (Molecules (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yun Liang *Department of Surgery, Mayo Clinic, Rochester, MN, United States.
Elif Ozdogan *Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
Michael J HansenDepartment of Immunology, Mayo Clinic, Rochester, MN, United States.
Hui TangDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
Ishran SaadiqDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
Kyra L JordanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
James D KrierDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
Deep B GandhiDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
Joseph P GrandeDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States.
Timucin TanerDepartment of Surgery, Mayo Clinic, Rochester, MN, United States.

Funding

Obesity-induced dysfunction of human MSC in peripheral microvascular repairR01HL158691 · NHLBI · MAYO CLINIC ROCHESTER · PI Alfonso Eirin, Lilach O Lerman · 2022 to 2026
$3.4M
Obesity-induced mesenchymal stem cell senescenceR01DK120292 · NIDDK · MAYO CLINIC ROCHESTER · PI LERMAN, LILACH O · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL158691NIDDK NIH HHS R01 DK120292
6 · The paper itself

Abstract

Introduction: The immunomodulatory properties of mesenchymal stromal cells (MSC) have been well-characterized in Method: To test these observations Results: The stenotic kidney volume was smaller in all RAS mice, confirming significant injury, and was improved by infusion of all MSC types. All MSC-infused groups had lower levels of plasma renin and proteinuria compared to untreated RAS. Serum creatinine improved in micetreated with BM- and L-MSC. All types of MSC located to and were retained within the stenotic kidneys, but L-MSC retention was significantly higher than A- and BM-MSC. While all groups of MSC-treated mice displayed reduced overall inflammation and macrophage counts, L-MSC showed superior potency Discussion: These

Indexed as

IschemiaLiverMacrophagesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAnimalsDisease Models, AnimalHumansInflammationKidneyMacrophage ActivationMaleMiceRenal Artery Obstructionimmunomodulationinflammationliver tolerancemesenchymal stromal cellsrenal artery stenosis

Identifiers

PMID39104523
PMCPMC11298378

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.