Evidence map›Paper›PMID 39104416›Full record

ArticleiScience2024

Respiratory infection with influenza A virus delays remyelination and alters oligodendrocyte metabolism.

Allison Y Louie, Jenny Drnevich, Jennifer L Johnson, Meagan Woodard, Anna V Kukekova, Rodney W Johnson, Andrew J Steelman

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Allison Y LouieNeuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jenny DrnevichRoy J. Carver Biotechnology Center, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jennifer L JohnsonDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Meagan WoodardDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Anna V KukekovaDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Rodney W JohnsonNeuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Andrew J SteelmanNeuroscience Program, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Funding

Molecular Mechanisms of Social BehaviorR35GM144276 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ANNA KUKEKOVA · 2022 to 2026
$2.1M
Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
The gut-brain axis and age-related microglial cell dysfunctionRF1AG059622 · NIA · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI JOHNSON, RODNEY W · 2018 to 2018
$1.9M
Upper-respiratory infection, oligodendrocyte plasticity and behaviorR21NS121741 · NINDS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI STEELMAN, ANDREW JONATHAN · 2021 to 2021
$406k
NIA NIH HHS RF1 AG059622NIBIB NIH HHS T32 EB019944NIGMS NIH HHS R35 GM144276NINDS NIH HHS R21 NS121741
6 · The paper itself

Abstract

Peripheral viral infection disrupts oligodendrocyte (OL) homeostasis such that endogenous remyelination may be affected. Here, we demonstrate that influenza A virus infection perpetuated a demyelination- and disease-associated OL phenotype following cuprizone-induced demyelination that resulted in delayed OL maturation and remyelination in the prefrontal cortex. Furthermore, we assessed cellular metabolism

Indexed as

cellular neurosciencemolecular neuroscienceneuroscienceomicstranscriptomics

Identifiers

PMID39104416
PMCPMC11298649

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.