Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Carley G StewartDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.
Brieanna M HilkinWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Nicholas D GansemerWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Ryan J AdamWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States.
David W DickDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-2453-2429
John J SunderlandDepartment of Radiology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States.
David A StoltzDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-0893-9015
Joseph ZabnerDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0002-9606-1339
Mahmoud H Abou AlaiwaDepartment of Biomedical Engineering, University of Iowa, Iowa City, Iowa, United States.ORCID 0000-0003-4525-0217
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector CoreP01HL051670 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 1993 to 2019
$36.5M
Respiratory virus infection in early cystic fibrosis lung diseaseP01HL091842 · NHLBI · UNIVERSITY OF IOWA · PI ZABNER, JOSEPH · 2008 to 2022
$34.2M
Airway Alkalinization and Repurposing Tromethamine as a Therapeutic Approach in Cystic FibrosisR01HL136813 · NHLBI · UNIVERSITY OF IOWA · PI STOLTZ, DAVID A, ZABNER, JOSEPH · 2017 to 2021
$5.3M
Contribution of Small Airways to Mucociliary Transport DysfunctionR01HL167025 · NHLBI · UNIVERSITY OF IOWA · PI Mahmoud Abou Alaiwa · 2023 to 2026
$2.8M
Mechanisms of impaired mucociliary transport in CF airway diseaseK08HL135433 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2017 to 2021
$801k
Mechanism for Hypertonic Saline Effect on Mucociliary TransportR56HL147073 · NHLBI · UNIVERSITY OF IOWA · PI ABOU ALAIWA, MAHMOUD · 2020 to 2020
$465k
Cystic Fibrosis Foundation (CFF) ABOU20A0-KBHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL051670HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL091842HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL135433HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL136813HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL167025NHLBI NIH HHS K08 HL135433NHLBI NIH HHS P01 HL051670NHLBI NIH HHS P01 HL091842NHLBI NIH HHS R01 HL136813NHLBI NIH HHS R01 HL167025NHLBI NIH HHS R56 HL147073NIEHS NIH HHS P30 ES005605
6 · The paper itself
Abstract
Cystic fibrosis (CF) is a genetic disorder characterized by recurrent airway infections, inflammation, impaired mucociliary clearance, and progressive decline in lung function. The disease may start in the small airways; however, this is difficult to prove due to the limited accessibility of the small airways with the current single-photon mucociliary clearance assay. Here, we developed a dynamic positron emission tomography assay with high spatial and temporal resolution. We tested that mucociliary clearance is abnormal in the small airways of newborn cystic fibrosis pigs. Clearance of [
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mucociliary clearance is impaired in small airways of cystic fibrosis pigs. · full record | OpenQuestion