Evidence map›Paper›PMID 39104250›Full record

ArticleAIDS research and human retroviruses2024

PET/CT Targeted Tissue Sampling Reveals Intravenously Administered HGN194 IgG1 Affects HIV Distribution after Rectal Exposure.

Roslyn A Taylor, Sixia Xiao, Ann M Carias, Michael D McRaven, Divya N Thakkar, Mariluz Araínga, Ramon Lorenzo-Redondo, Edward J Allen, Kenneth A Rogers, Sidath C Kumarapperuma and 12 more

Abstract read
In one paragraph

Article in AIDS research and human retroviruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Roslyn A TaylorDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Sixia XiaoDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ann M CariasDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Michael D McRavenDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Divya N ThakkarDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Mariluz AraíngaNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, USA.
Ramon Lorenzo-RedondoDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Edward J AllenDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Kenneth A RogersNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, USA.
Sidath C KumarapperumaResearch Imaging Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.
Siqi GongNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, USA.
Meegan R AndersonDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Yanique ThomasDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Patrick J MaddenDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Davide CortiHumabs Biomed, a subsidiary of Vir Biotechnology Inc, Bellinzona, Switzerland.
Elisabetta CameroniHumabs Biomed, a subsidiary of Vir Biotechnology Inc, Bellinzona, Switzerland.
Antonio LanzavecchiaHumabs Biomed, a subsidiary of Vir Biotechnology Inc, Bellinzona, Switzerland.
Beth GoinsResearch Imaging Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.
Peter FoxResearch Imaging Institute, University of Texas Health San Antonio, San Antonio, Texas, USA.
Francois J VillingerNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, USA.
Ruth M RuprechtNew Iberia Research Center, University of Louisiana at Lafayette, Lafayette, Louisiana, USA.
Thomas J HopeDepartment of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0001-7183-8319

Funding

The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Virology and ImmunologyP01AI048240 · NIAID · UNIVERSITY OF WASHINGTON · PI RUPRECHT, RUTH MARGRIT · 2000 to 2020
$46.7M
CHEETAH Center for the Structural Biology of HIV Infection, Restriction, and Viral DynamicsU54AI170856 · NIAID · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI WALTHER H MOTHES · 2022 to 2026
$34.4M
Virus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9M
Identification of the Initial Targets of Transmission R37AI094595 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Thomas Hope · 2017 to 2026
$10.0M
Understanding the mechanism(s) of systemic antibody delivery, distribution, and localization to mucosal sites in the in vivo macaque modelK01OD026571 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CARIAS, ANN M · 2018 to 2020
$1.1M
NIAID NIH HHS P01 AI048240NIAID NIH HHS P50 AI150464NIAID NIH HHS R37 AI094595NIAID NIH HHS U54 AI170856NIH HHS K01 OD026571NIH HHS P51 OD011133
6 · The paper itself

Abstract

Neutralizing monoclonal antibodies hold great potential for prevention of human immunodeficiency virus (HIV) acquisition. IgG is the most abundant antibody in human serum, has a long half-life, and potent effector functions, making it a prime candidate for an HIV prevention therapeutic. We combined Positron Emission Tomography imaging and fluorescent microscopy of

Indexed as

HIV AntibodiesHIV InfectionsImmunoglobulin GPositron Emission Tomography Computed TomographyAdministration, IntravenousAnimalsAntibodies, MonoclonalAntibodies, NeutralizingHIV-1HumansMiceRectumAntibodies, MonoclonalAntibodies, NeutralizingHIV AntibodiesImmunoglobulin GantibodiesHIV transmissionmucosal barriersmucosal immunology

Identifiers

PMID39104250
PMCPMC11876819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.