Evidence map›Paper›PMID 39104028›Full record

ArticleJournal of dental research2024

Topical Vitamin D Prevents Bone Loss and Inflammation in a Mouse Model.

K L Kirkwood, T E Van Dyke, C L Kirkwood, L Zhang, J Panezai, A E Duran-Pinedo, E L Figgins, L K Ryan, J J Frias-Lopez, G Diamond

Abstract read
In one paragraph

Article in Journal of dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Vitamin DInternational journal of molecular sciences · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

K L KirkwoodDepartment of Oral Biology, University at Buffalo, Buffalo, New York, USA.ORCID 0000-0003-4519-8973
T E Van DykeDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA, USA.ORCID 0000-0003-0856-3396
C L KirkwoodDepartment of Oral Biology, University at Buffalo, Buffalo, New York, USA.
L ZhangDepartment of Oral Biology, University at Buffalo, Buffalo, New York, USA.
J PanezaiDepartment of Applied Oral Sciences, The Forsyth Institute, Cambridge, MA, USA.
A E Duran-PinedoDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
E L FigginsDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
L K RyanDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.
J J Frias-LopezDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.ORCID 0000-0002-2097-3171
G DiamondDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA.ORCID 0000-0002-3596-9773

Funding

Mechanisms of Resolvin E1 in Periodontal RegenerationR01DE025020 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI GUASTALDI, FERNANDO, VAN DYKE, THOMAS ELLIOTT · 2015 to 2023
$4.9M
Topical Vitamin D and Periodontal DiseaseR01DE028883 · NIDCR · UNIVERSITY OF LOUISVILLE · PI GILL DIAMOND, Keith L Kirkwood · 2021 to 2026
$3.2M
NIDCR NIH HHS R01 DE025020NIDCR NIH HHS R01 DE028883
6 · The paper itself

Abstract

There is a strong association between vitamin D levels and periodontal disease based on numerous epidemiological studies. We have previously shown that experimental deficiency of serum vitamin D in mice leads to gingival inflammation and alveolar bone loss. Treatment of cultured oral epithelial cells with the active form of vitamin D, 1,25(OH)

Indexed as

Administration, TopicalAlveolar Bone LossDisease Models, AnimalPeriodontitisVitamin DAnimalsCalcitriolGingivaGingivitisMiceMice, Inbred C57BLCalcitriolVitamin Dcytokineinnate immunitylipidomicsmicrobiomeperiodontitisresolution

Identifiers

PMID39104028
PMCPMC11465324

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.