Evidence map›Paper›PMID 39103958›Full record

ArticleJournal of animal science and biotechnology2024

Astragalus polysaccharides-induced gut microbiota play a predominant role in enhancing of intestinal barrier function of broiler chickens.

Jiantao Yang, Yanpeng Sun, Qianggang Wang, Shanglin Yu, Yanhe Li, Bin Yao, Xiaojun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Plants (Basel, Switzerland) · 2026
    Article
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  18. The role ofFrontiers in immunology · 2026
    Review
  19. Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiantao Yang *College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yanpeng Sun *College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Qianggang WangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Shanglin YuCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Yanhe LiCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China.
Bin YaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China. yaobin@caas.cn.
Xiaojun YangCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi, China. yangxj@nwsuaf.edu.cn.

Funding

National key Research & Development Program of China 2023YFD1301400National Natural Science Foundation of China 32272916the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 019HBGC-16the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 2019ZDXM3-02the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 2021TD-30the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 2022GD-TSLD-46-0302the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 2023GXJS-02-01the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department 2023KXJ-243the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department K3031223075the Program for Shaanxi Science & Technology from Shaanxi Provincial Science and Technology Department L2022-QCYZX-NY-004
6 · The paper itself

Abstract

backgroundThe intestinal barrier is the first line of defense against intestinal invasion by pathogens and foreign antigens and is closely associated with the gut microbiota. Astragalus polysaccharides (APS) have a long history of use in traditional Chinese medicine owing to its protective properties against intestinal barrier function. The mechanism of APS-induced gut microbiota enhancing intestinal barrier function is urgently needed.

resultsDietary polysaccharide deprivation induced intestinal barrier dysfunction, decreased growth performance, altered microbial composition (Faecalibacterium, Dorea, and Coprobacillus), and reduced isobutyrate concentration. The results showed that APS facilitates intestinal barrier function in broiler chickens, including a thicker mucus layer, reduced crypt depth, and the growth of tight junction proteins. We studied the landscape of APS-induced gut microbiota and found that APS selectively promoted the growth of Parabacteroides, a commensal bacterium that plays a predominant role in enhancing intestinal barrier function. An in vitro growth assay further verified that APS selectively increased the abundance of Parabacteroides distasonis and Bacteroides uniformis. Dietary APS supplementation increased the concentrations of isobutyrate and bile acid (mainly chenodeoxycholic acid and deoxycholate acid) and activated signaling pathways related to intestinal barrier function (such as protein processing in the endoplasmic reticulum, tight junctions, and adherens junction signaling pathways).

conclusionsAPS intervention restored the dietary polysaccharide-induced dysfunction of the intestinal barrier by selectively promoting the abundance of Parabacteroides distasonis, and increasing the concentrations of isobutyrate and bile acids (mainly CDCA and DCA). These findings suggest that APS-induced gut microbiota and metabolic niches are promising strategies for enhancing intestinal barrier function.

Indexed as

Astragalus polysaccharidesBroilerGut microbiotaIntestinal barrier function

Identifiers

PMID39103958
PMCPMC11302362

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.