Evidence map›Paper›PMID 39103947›Full record

Trial reportJournal of neuroengineering and rehabilitation2024

Clinical and neurophysiological effects of bilateral repetitive transcranial magnetic stimulation and EEG-guided neurofeedback in Parkinson's disease: a randomized, four-arm controlled trial.

Juan Pablo Romero, Marcos Moreno-Verdú, Aida Arroyo-Ferrer, J Ignacio Serrano, Jaime Herreros-Rodríguez, Juan García-Caldentey, Eduardo Rocon de Lima, María Dolores Del Castillo

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04017481 (Development and Clinical Validation of a Rehabilitation Platform Based on Neuromodulation for Patients With Motor Control Disorders), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04017481 nacompletednot on this map

Development and Clinical Validation of a Rehabilitation Platform Based on Neuromodulation for Patients With Motor Control Disorders

TypeinterventionalSponsorUniversidad Francisco de VitoriaRan2016 to 2019Enrolled50ConditionsParkinson DiseaseArmsRepetitive transcranial magnetic stimulation (rTMS), EEG guided Neurofeedback (NFB)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Juan Pablo RomeroBrain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain.
Marcos Moreno-VerdúBrain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain. marcos.morenoverdu@uclouvain.be.
Aida Arroyo-FerrerBrain Injury and Movement Disorders Neurorehabilitation Group (GINDAT), Institute of Life Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, Spain.
J Ignacio SerranoNeural and Cognitive Engineering Group, Centre for Automation and Robotics, Spanish National Research Council, Madrid, Spain.
Jaime Herreros-RodríguezDepartment of Neurology, University Hospital Infanta Leonor, Madrid, Spain.
Juan García-CaldenteyDepartment of Neurology, Hospital Quirón Palmaplanas, Palma de Mallorca, Spain.
Eduardo Rocon de LimaNeural and Cognitive Engineering Group, Centre for Automation and Robotics, Spanish National Research Council, Madrid, Spain.
María Dolores Del CastilloNeural and Cognitive Engineering Group, Centre for Automation and Robotics, Spanish National Research Council, Madrid, Spain.

Funding

Ministerio de Ciencia e Innovación PID2020-113222RBC21/AEI/10.13039/501100011033Ministerio de Economía y Competitividad DPI2015-68664-C4-1-R (MINECO/FEDER)Ministerio de Economía y Competitividad DPI2015-68664-C4-3-R (MINECO/FEDER)
6 · The paper itself

Abstract

backgroundRepetitive Transcranial Magnetic Stimulation (rTMS) and EEG-guided neurofeedback techniques can reduce motor symptoms in Parkinson's disease (PD). However, the effects of their combination are unknown. Our objective was to determine the immediate and short-term effects on motor and non-motor symptoms, and neurophysiological measures, of rTMS and EEG-guided neurofeedback, alone or combined, compared to no intervention, in people with PD.

methodsA randomized, single-blinded controlled trial with 4 arms was conducted. Group A received eight bilateral, high-frequency (10 Hz) rTMS sessions over the Primary Motor Cortices; Group B received eight 30-minute EEG-guided neurofeedback sessions focused on reducing average bilateral alpha and beta bands; Group C received a combination of A and B; Group D did not receive any therapy. The primary outcome measure was the UPDRS-III at post-intervention and two weeks later. Secondary outcomes were functional mobility, limits of stability, depression, health-related quality-of-life and cortical silent periods. Treatment effects were obtained by longitudinal analysis of covariance mixed-effects models.

resultsForty people with PD participated (27 males, age = 63 ± 8.26 years, baseline UPDRS-III = 15.63 ± 6.99 points, H&Y = 1-3). Group C showed the largest effect on motor symptoms, health-related quality-of-life and cortical silent periods, followed by Group A and Group B. Negligible differences between Groups A-C and Group D for functional mobility or limits of stability were found.

conclusionsThe combination of rTMS and EEG-guided neurofeedback diminished overall motor symptoms and increased quality-of-life, but this was not reflected by changes in functional mobility, postural stability or depression levels.

trial registrationNCT04017481.

Indexed as

ElectroencephalographyNeurofeedbackParkinson DiseaseTranscranial Magnetic StimulationAgedFemaleHumansMaleMiddle AgedMotor CortexQuality of LifeSingle-Blind MethodTreatment OutcomeEEGMotor symptomsNeurofeedbackNon-invasive neuromodulationParkinson’s diseaseRepetitive transcranial magnetic stimulation

Identifiers

PMID39103947
PMCPMC11299373

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.