Evidence map›Paper›PMID 39103890›Full record

ArticleEuropean journal of medical research2024

Anticancer effects of Erzhimaoling decoction in high-grade serous ovarian cancer in vitro and in vivo.

Li Yang, Jingfang Liu, Jiejie Zhang, Feng Shao, Yanlu Jin, Jie Xing, Heran Zhou, Aijun Yu

Abstract read
In one paragraph

Article in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li Yang *Department of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Jingfang Liu *Department of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Jiejie ZhangDepartment of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Feng ShaoDepartment of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Yanlu JinDepartment of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Jie XingDepartment of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China.
Heran ZhouDepartment of Oncology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, No. 453 Stadium Road, Hangzhou, 310007, Zhejiang, China. heranzhou100@163.com.
Aijun YuDepartment of Gynecological Oncology, Zhejiang Cancer Hospital, No. 1 Banshan East Road, Hangzhou, 310022, Zhejiang, China. yaj1993@126.com.

Funding

Chinese Medicine Research Program of Zhejiang province 2022ZQ018National Natural Science Foundation of China 82274266
6 · The paper itself

Abstract

backgroundHigh-grade serous ovarian cancer (HGSOC) is a common gynecologic malignancy with a poor prognosis. The traditional Chinese medicine formula Erzhimaoling decoction (EZMLD) has anticancer potential. This study aims to elucidate the anticancer effects of EZMLD on HGSOC in vitro and in vivo. MATERIALS AND

methodsEZMLD-containing serum was prepared from Sprague-Dawley rats for treating SKOV3 ovarian cancer cells at varying concentrations for 24 h and 48 h to determine the IC

resultsIn vitro, EZMLD-containing serum had IC

conclusionsEZMLD has therapeutic potential for ovarian cancer and may be considered for other cancer types. Future research may explore its broader effects beyond cell apoptosis.

Indexed as

Antineoplastic Agents, PhytogenicCarcinoma, Ovarian EpithelialDrugs, Chinese HerbalOvarian NeoplasmsAnimalsApoptosisCell Line, TumorCell SurvivalFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansInhibitory Concentration 50Keratin-8MaleMethyltransferasesAntineoplastic Agents, PhytogenicDrugs, Chinese HerbalKeratin-8KRT8 protein, humanMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanApoptosisFASKRT8METTL14METTL3SKOV3Traditional Chinese Medicine

Identifiers

PMID39103890
PMCPMC11299366

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.