ArticleBiotechnology for biofuels and bioproducts2024
Efficiency of acetate-based isopropanol synthesis in Escherichia coli W is controlled by ATP demand.
Article in Biotechnology for biofuels and bioproducts, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The potential of syngas as a central mediator for a carbon-agnostic circular economy.Nature communications · 2026Review
- Demonstration and technoeconomic analysis of dodecanol production from acetate using metabolically engineered Escherichia coli.Metabolic engineering · 2026Article
- Improving sustainable isopropanol production in engineered Escherichia coli W via oxygen limitation.Microbial cell factories · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundDue to increasing ecological concerns, microbial production of biochemicals from sustainable carbon sources like acetate is rapidly gaining importance. However, to successfully establish large-scale production scenarios, a solid understanding of metabolic driving forces is required to inform bioprocess design. To generate such knowledge, we constructed isopropanol-producing Escherichia coli W strains.
resultsBased on strain screening and metabolic considerations, a 2-stage process was designed, incorporating a growth phase followed by a nitrogen-starvation phase. This process design yielded the highest isopropanol titers on acetate to date (13.3 g L
conclusionsUsing the newly gained system-level understanding for isopropanol production from acetate, we assessed possible engineering approaches and propose process designs to maximize production. Collectively, our work contributes to the establishment and optimization of acetate-based bioproduction systems.
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