Evidence map›Paper›PMID 39103758›Full record

ArticleBMC cancer2024

Effects of brain radiotherapy strategies on survival in the era of MRI for patients with limited stage small cell lung cancer.

Nan Yao, Zhaohui Qin, Meng Chen, Lingling Hu, Ji Ma, Jiaying Lu, Shaodong Tong, Na Li, Yuanhu Yao

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nan Yao *Department of Radiation Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi, 214023, Jiangsu, China.
Zhaohui Qin *Research Center for Medical and Health Emergency Rescue, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.
Meng Chen *Department of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, 221009, Jiangsu, China.
Lingling HuGraduate School of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Ji MaGraduate School of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Jiaying LuGraduate School of Xuzhou Medical University, Xuzhou, 221000, Jiangsu, China.
Shaodong TongDepartment of Radiation Oncology, The Third People's Hospital of Xuzhou, Xuzhou, 221005, Jiangsu, China.
Na LiDepartment of Radiation Oncology, Xuzhou Central Hospital, Xuzhou, 221009, Jiangsu, China.
Yuanhu YaoDepartment of Radiation Oncology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi, 214023, Jiangsu, China. yyhxzsn@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeIn the context of the widespread availability of magnetic resonance imaging (MRI) and aggressive salvage irradiation techniques, there has been controversy surrounding the use of prophylactic cranial irradiation (PCI) for small-cell lung cancer (SCLC) patients. This study aimed to explore whether regular brain MRI plus salvage brain irradiation (SBI) is not inferior to PCI in patients with limited-stage SCLC (LS-SCLC).

methodsThis real-world multicenter study, which was conducted between January 2014 and September 2020 at three general hospitals, involved patients with LS-SCLC who had a good response to initial chemoradiotherapy and no brain metastasis confirmed by MRI. Overall survival (OS) was compared between patients who did not receive PCI for various reasons but chose regular MRI surveillance and followed salvage brain irradiation (SBI) when brain metastasis was detected and patients who received PCI.

results120 patients met the inclusion criteria. 55 patients received regular brain MRI plus SBI (SBI group) and 65 patients received PCI (PCI group). There was no statistically significant difference in median OS between the two groups (27.14 versus 33.00 months; P = 0.18). In the SBI group, 32 patients underwent whole brain radiotherapy and 23 patients underwent whole brain radiotherapy + simultaneous integrated boost. On multivariate analysis, only extracranial metastasis was independently associated with poor OS in the SBI group.

conclusionThe results of this real-world study showed that MRI surveillance plus SBI is not inferior to PCI in OS for LS-SCLC patients who had a good response to initial chemoradiotherapy.

Indexed as

Brain NeoplasmsCranial IrradiationLung NeoplasmsMagnetic Resonance ImagingSalvage TherapySmall Cell Lung CarcinomaAdultAgedChemoradiotherapyFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesBrain metastasesLimited-stage small cell lung cancerMagnetic resonance imagingProphylactic cranial irradiation

Identifiers

PMID39103758
PMCPMC11302834

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.