Evidence map›Paper›PMID 39103638›Full record

ArticleCardiovascular and interventional radiology2024

Transarterial Embolization Enhances Programmed Cell Death Ligand 1 Expression and Influences CD8

Shen Zhang, Lin Xu, Jia-Qing Li, Ming-Zhan Du, Yu Yin, Bin-Yan Zhong, Han-Si Liang, Wan-Ci Li, Cai-Fang Ni, Xiao-Li Zhu

Abstract read
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In one paragraph

Article in Cardiovascular and interventional radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shen ZhangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Lin XuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Jia-Qing LiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Ming-Zhan DuDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Yu YinDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Bin-Yan ZhongDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Han-Si LiangJiangu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wan-Ci LiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Cai-Fang NiDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China.
Xiao-Li ZhuDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, 215006, China. zhuxiaoli90@163.com.ORCID http://orcid.org/0000-0002-5504-9528

Funding

Jiangsu Provincial Key Research and Development Program BE2021648Natural Science Foundation of Jiangsu Province SBK2023022210
6 · The paper itself

Abstract

purposeTo investigate the influence of transarterial embolization (TAE) on programmed cell death-ligand 1(PD-L1) expression and CD8 MATERIALS AND

methodsAn orthotopic HCC model was established in twenty SD rats treated with TAE (lipiodol, n = 10) or sham (normal saline, n = 10) using homologous N1S1 hepatoma cells. Rats were euthanized 1 week after embolization. Flow cytometry was used to assess the proportion of CD4

resultsThe CD4/CD8 ratio and PD-1

conclusionsImmune cells are distributed unevenly in the tumours after TAE. The intrinsic induction state of the tumour after embolization may be insufficient to elicit a maximal response to PD-1/PD-L1 inhibitors.

Indexed as

B7-H1 AntigenCarcinoma, HepatocellularCD8-Positive T-LymphocytesEmbolization, TherapeuticLiver NeoplasmsRats, Sprague-DawleyAnimalsDisease Models, AnimalEthiodized OilFlow CytometryLiver Neoplasms, ExperimentalMaleRatsB7-H1 AntigenEthiodized OilCD8+T lymphocytesHepatocellular carcinomaProgrammed cell death ligand 1Transarterial embolizationTumour immune microenvironment

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.