Evidence map›Paper›PMID 39103576›Full record

ArticleNature immunology2024

Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity.

Rongchuan Zhao, Jiao Yang, Yunjiao Zhai, Hong Zhang, Yuanshuai Zhou, Lei Hong, Detian Yuan, Ruilong Xia, Yanxiang Liu, Jinlin Pan and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Dysregulated immunometabolism in gut inflammation.Acta biochimica et biophysica Sinica · 2026
    Review
  7. Machine learning and multi-omics integration identifies immunological predictors and mechanistic insights in autoimmune encephalitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rongchuan Zhao *Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Jiao Yang *Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.ORCID http://orcid.org/0000-0002-1553-5425
Yunjiao ZhaiAdvanced Medical Research Institute, Shandong University, Jinan, China.
Hong ZhangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Yuanshuai ZhouSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Lei HongSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Detian YuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ruilong XiaThe First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, China.
Yanxiang LiuSuzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China.
Jinlin PanSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Shaheryar ShafiSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.ORCID http://orcid.org/0000-0002-1936-4838
Guohua ShiSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Ruobing ZhangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Dingsan LuoSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Jinyun YuanSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China.
Dejing PanCAM-SU Genomic Resource Center, Soochow University, Suzhou, China.
Changgeng PengThe First Rehabilitation Hospital of Shanghai, Brain and Spinal Cord Innovation Research Center, School of Medicine, Advanced Institute of Translational Medicine, Tongji University, Shanghai, China. changgeng.peng@tongji.edu.cn.ORCID http://orcid.org/0000-0002-6707-2717
Shiyang LiAdvanced Medical Research Institute, Shandong University, Jinan, China. lishiyang@sdu.edu.cn.ORCID http://orcid.org/0000-0003-1487-4991
Minxuan SunSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, China. minxuan.sun@sibet.ac.cn.ORCID http://orcid.org/0000-0003-2033-6268

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nucleophosmin 1 (NPM1) is commonly mutated in myelodysplastic syndrome (MDS) and acute myeloid leukemia. Concurrent inflammatory bowel diseases (IBD) and MDS are common, indicating a close relationship between IBD and MDS. Here we examined the function of NPM1 in IBD and colitis-associated colorectal cancer (CAC). NPM1 expression was reduced in patients with IBD. Npm1

Indexed as

ColitisImmunity, MucosalMice, KnockoutMitochondriaNuclear ProteinsNucleophosminOxidative PhosphorylationAnimalsColorectal NeoplasmsDextran SulfateFemaleHumansImmunity, InnateInflammatory Bowel DiseasesInterleukin-22InterleukinsDextran SulfateInterleukin-22InterleukinsNPM1 protein, humanNpm1 protein, mouseNuclear ProteinsNucleophosmin

Identifiers

PMID39103576
PMCPMC11362010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.