ArticleNature microbiology2024
Aspergillus cvjetkovicii protects against phytopathogens through interspecies chemical signalling in the phyllosphere.
Article in Nature microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- ZmHPATR1 orchestrates phyllosphere organic acid flux to recruit Sphingomonas and enhance resistance of maize to Curvularia leaf spot.The New phytologist · 2026Article
- Keystone taxa of phyllosphere microbiome confer resistance to citrus bacterial canker in pomelo via multiple mechanisms.Journal of integrative plant biology · 2026Article
- Review
- Anthracnose drives assembly of phyllosphere epiphytic bacterial communities to increase disease resistance.NPJ biofilms and microbiomes · 2026Article
- Phyllosphere Keystone Beneficial Specialists Enhance Yield in Nutrient Deficiency-Resistant Sorghum Cultivars.Plant, cell & environment · 2026Article
- Microbiome-mediated environmental adaptation in tea plants and its potential applications.Journal of advanced research · 2026Review
- What do we know about the seed microbiome?Microbiome · 2026Review
- Mechanistic Insights for Microbiome Application in Plant Disease Resistance.Molecular plant pathology · 2026Review
- The Multifaceted Functions of Plant Asparagine Synthetase: Regulatory Mechanisms and Functional Diversity in Growth and Defense.Plants (Basel, Switzerland) · 2026Review
- Lipopeptide Engineering: From Natural Origins to Rational Design Against Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2026Review
- A novel internal reference microorganism-based method reveals wild-enrichedFrontiers in microbiology · 2026Article
- Integrating microbiome and machine learning for precision diagnosis of rice bakanae disease.Plant methods · 2025Article
- Multi-omics analyses reveal the virulence differentiation underlying natural variation inApplied and environmental microbiology · 2025Article
- Plant-microbiome interactions suppress Fusarium wilt by enriching beneficial Aspergillus in the tobacco rhizosphere.Environmental microbiome · 2025Article
- Global variation in plant-beneficial bacteria in soil under pesticide stress.Nature communications · 2025Article
- Harnessing chemical communication in plant-microbiome and intra-microbiome interactions.Journal of Zhejiang University. Science. B · 2025Review
- The Role of Phyllosphere Microbes and Viruses in Biocontrol of Pathogenic Fungi.Microbial biotechnology · 2025Review
- Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Funding
Abstract
Resident microbiota produces small molecules that influence the chemical microenvironments on leaves, but its signalling roles in pathogen defence are not yet well understood. Here we show that Aspergillus cvjetkovicii, enriched in rice leaf microbiota, subverts Rhizoctonia solani infections via small-molecule-mediated interspecies signalling. 2,4-Di-tert-butylphenol (2,4-DTBP), identified as a key signalling molecule within the Aspergillus-enriched microbiota, effectively neutralizes reactive oxygen species-dependent pathogenicity by switching off bZIP-activated AMT1 transcription in R. solani. Exogenous application of A. cvjetkovicii and 2,4-DTBP demonstrated varying degrees of protective effects against R. solani infection in diverse crops, including cucumber, maize, soybean and tomato. In rice field experiments, they reduced the R. solani-caused disease index to 19.7-32.2%, compared with 67.2-82.6% in the control group. Moreover, 2,4-DTBP showed activity against other rice phytopathogens, such as Fusarium fujikuroi. These findings reveal a defensive strategy against phytopathogens in the phyllosphere, highlighting the potential of symbiotic microbiota-driven neutralization of pathogenicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.