ArticleNature neuroscience2024
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
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Article in Nature neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
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Who cites it
80 citing papers in PubMed.
- Spatiotemporal AI-based modeling of gene regulation and variant effects in the developing human brain using Seal.Nature neuroscience · 2026Article
- Accurate and well-powered case-control analysis of spatial molecular data.Nature methods · 2026Article
- mTORC1 Activation Links Chronic Stress to Meso-Circuit Desynchronization and Accelerated Amyloid Pathology via Autophagic Dysfunction.CNS neuroscience & therapeutics · 2026Article
- Review
- Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer's disease.Nature communications · 2026Article
- Beyond the Wiring: White Matter as a Dynamic Regulator of Brain Function and Disease.Neuroscience bulletin · 2026Review
- Oligodendrocyte-Targeted SGK1.1 Inhibition Alleviates White Matter Injury and Cognitive Impairment in Alzheimer's Disease via Modulation of HDAC2 Phosphorylation.CNS neuroscience & therapeutics · 2026Article
- When myelin breaks, tau aggregates - a new perspective on Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- A First-In-Class Antibody Enabling Detection of Altered Peripheral Non-Phosphorylated Clusterin With Translational Potential in Dementia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer's Disease Model Mice.Biomolecules · 2026Article
- Passive amyloid-β immunotherapy in Alzheimer's disease: a multicellular clearance system beyond plaque removal.Molecular neurodegeneration · 2026Review
- Sequential associations of myelin dysfunction with Aβ and Tau pathology in Alzheimer's disease: a dynamic myelin perturbation.Alzheimer's research & therapy · 2026Article
- Oligodendroglial Mutant Huntingtin Contributes to Neuroinflammation in Huntington's Disease Mice.Neuroscience bulletin · 2026Article
- Life Cycle and Circadian Rhythms in Central Resident Immunity and Neuropsychiatric Pathology.Neuroscience bulletin · 2026Review
- Coordinated transcriptional shifts in microglia and oligodendrocytes from neurodevelopment to inflammaging.npj aging · 2026Article
- Considerations for the selection and phenotyping of mouse models for the study of Alzheimer's disease.STAR protocols · 2026Review
- MipSScs: Artificial neural network-based data integration of 2D/3D single-cell spatial RNA sequence data from virus-infected human cerebral organoids.bioRxiv : the preprint server for biology · 2026Article
- Systematic identification of cell-cell interactions associated with the severity of patients with Alzheimer's disease.Journal of Alzheimer's disease : JAD · 2026Article
- Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease.Neuroprotection (Chichester, England) · 2026Review
- A Question of Origins: Non-neuronal Sources of Amyloid-β.Neuroscience bulletin · 2026Review
20 more citing papers are in PubMed but not listed here.
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Authors and funding
35 authors.
Andrew Octavian Sasmita *Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. sasmita@mpinat.mpg.de.ORCID http://orcid.org/0000-0001-7379-6749
Constanze Depp *Department of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. depp@mpinat.mpg.de.ORCID http://orcid.org/0000-0003-2868-6932
Taisiia NazarenkoDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Ting SunDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7104-7215
Sophie B SiemsDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Erinne Cherisse OngDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0009-0002-4047-7340
Yakum B NkehDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0009-0006-9601-4408
Carolin BöhlerDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Xuan YuDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Bastian BuesSchool of Biochemistry and Cell Biology, Biosciences Institute, University College Cork, Cork, Ireland.ORCID http://orcid.org/0000-0002-8302-6235
Lisa EvangelistaInstitute for Stroke and Dementia Research, Klinikum Der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.ORCID http://orcid.org/0009-0006-2396-4656
Shuying MaoDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Barbara MorgadoDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.ORCID http://orcid.org/0000-0001-8174-9301
Zoe WuDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Torben RuhwedelDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-9535-9395
Swati SubramanianDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Friederike BörensenDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Katharina OverhoffDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Lena SpiethDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Stefan A BerghoffDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Katherine Rose SadleirKen and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Robert VassarKen and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Simone EggertDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Sandra GoebbelsDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science Wako, Saitama, Japan.ORCID http://orcid.org/0000-0002-9659-9251
Takaomi SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science Wako, Saitama, Japan.ORCID http://orcid.org/0000-0003-1970-6903
Gesine SaherDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0003-3507-9604
Wiebke MöbiusDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.ORCID http://orcid.org/0000-0002-2902-7165
Gonçalo Castelo-BrancoLaboratory of Molecular Neurobiology, Department of Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-2247-9393
Hans-Wolfgang KlafkiDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.
Oliver WirthsDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.ORCID http://orcid.org/0000-0002-4115-0334
Jens WiltfangDepartment of Psychiatry and Psychotherapy, University Medical Center, Georg-August University, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1492-5330
Sarah JäkelInstitute for Stroke and Dementia Research, Klinikum Der Universität München, Ludwig-Maximilians-Universität, Munich, Germany.
Riqiang YanDepartment of Neuroscience, UConn Health, Farmington, CT, USA.
Klaus-Armin NaveDepartment of Neurogenetics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany. nave@mpinat.mpg.de.ORCID http://orcid.org/0000-0001-8724-9666
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid-β (Aβ) is thought to be neuronally derived in Alzheimer's disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APP
Indexed as
Alzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesNeuronsOligodendrogliaPlaque, AmyloidAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalHumansMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBace1 protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.