ArticleCommunications biology2024
Critical dynamics in spontaneous EEG predict anesthetic-induced loss of consciousness and perturbational complexity.
Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is criticality a unified setpoint of brain function?Neuron · 2025Pooled it
- Recovery from disorders of consciousness: Lesions and GABAergic modulation in a biologically inspired spiking neural network.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cellular and Microcircuit Mechanisms of Anesthetic Disruption of Conscious-State Organization.Cells · 2026Review
- Ketamine Across the Dose-State Continuum: EEG Signatures, Network Dynamics, and Implications for Brain-State Monitoring in Anesthesia and Critical Care.Brain sciences · 2026Review
- Reframing "paradoxical" excitation: disentangling electroencephalogram complexity and entropy reveals resting-state dynamics associated with propofol susceptibility in healthy adults.British journal of anaesthesia · 2026Article
- Thermodynamics of consciousness: Non-equilibrium brain dynamics track conscious states.Cell reports · 2026Article
- Large-Scale Neural Recording Technologies for Investigating Circuit Dysfunction and Functional Biomarker Discovery in Animal Models of Alzheimer's Disease.International journal of molecular sciences · 2026Review
- A three-component dynamical index of consciousness-related neural organisation.Biological cybernetics · 2026Article
- Fractal dynamics of the healthy human brain: A subcortical-to-cortical gradient of temporal complexity.iScience · 2026Article
- Early reactivation of medial temporal lobe neurons during emergence from propofol anesthesia in neurosurgical patients.bioRxiv : the preprint server for biology · 2026Article
- Esketamine Preserves Network Connectivity and Promotes Recovery in Consciousness Disorders.CNS neuroscience & therapeutics · 2026Article
- Adversarial AI reveals mechanisms and treatments for disorders of consciousness.Nature neuroscience · 2026Article
- Characteristics of electroencephalographic changes induced by different hypnotics in elderly patients: a narrative review.Korean journal of anesthesiology · 2026Review
- Electrophysiological effects of psilocybin co-administered with midazolam.Translational psychiatry · 2026Article
- Cortical Mechanisms Contributing to Ketamine-Induced Dissociation.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2026Review
- Toward a true understanding of consciousness: the explanatory power behind the non-physicalist paradigm.Frontiers in human neuroscience · 2026Article
- A caveat regarding the unfolding argument: implications of plasticity.Neuroscience of consciousness · 2026Article
- Emergent flow theory: autonomic coherence as a gain parameter for the temporal architecture of conscious integration.Frontiers in integrative neuroscience · 2026Article
- Synergy mediates long-range correlations in the visual cortex near criticality.Frontiers in computational neuroscience · 2026Article
- Beyond the brain: a computational MRI-derived neurophysiological framework for robotic conscious capacity.Neuroscience and biobehavioral reviews · 2025Review
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9 authors.
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Abstract
Consciousness has been proposed to be supported by electrophysiological patterns poised at criticality, a dynamical regime which exhibits adaptive computational properties, maximally complex patterns and divergent sensitivity to perturbation. Here, we investigate dynamical properties of the resting-state electroencephalogram (EEG) of healthy subjects undergoing general anesthesia with propofol, xenon or ketamine. Importantly, all participants were unresponsive under anesthesia, while consciousness was retained only during ketamine anesthesia (in the form of vivid dreams), enabling an experimental dissociation between unresponsiveness and unconsciousness. For each condition, we measure (i) avalanche criticality, (ii) chaoticity, and (iii) criticality-related metrics, revealing that states of unconsciousness are characterized by a distancing from both avalanche criticality and the edge of chaos. We then ask whether these same dynamical properties are predictive of the perturbational complexity index (PCI), a TMS-based measure that has shown remarkably high sensitivity in detecting consciousness independently of behavior. We successfully predict individual subjects' PCI values with considerably high accuracy from resting-state EEG dynamical properties alone. Our results establish a firm link between perturbational complexity and criticality, and provide further evidence that criticality is a necessary condition for the emergence of consciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.