Evidence map›Paper›PMID 39103505›Full record

ArticleActa diabetologica2025

Vasorelaxant mechanisms of the antidiabetic anagliptin in rabbit aorta: roles of Kv channels and SERCA pump.

Ryeon Heo, Minju Park, Seo-Yeong Mun, Wenwen Zhuang, Junsu Jeong, Hongzoo Park, Eun-Taek Han, Jin-Hee Han, Wanjoo Chun, Won-Kyo Jung and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Acta diabetologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ryeon Heo *Department of Physiology, Seoul National University College of Medicine, Seoul, 03080, South Korea.
Minju Park *Department of Physiology, Institute of Medical Sciences, Kangwon National University School of Medicine, 1 Kangwondaehak-Gil, Chuncheon, 24341, South Korea.
Seo-Yeong MunDepartment of Physiology, Institute of Medical Sciences, Kangwon National University School of Medicine, 1 Kangwondaehak-Gil, Chuncheon, 24341, South Korea.
Wenwen ZhuangDepartment of Physiology, Institute of Medical Sciences, Kangwon National University School of Medicine, 1 Kangwondaehak-Gil, Chuncheon, 24341, South Korea.
Junsu JeongDepartment of Physiology, Institute of Medical Sciences, Kangwon National University School of Medicine, 1 Kangwondaehak-Gil, Chuncheon, 24341, South Korea.
Hongzoo ParkDepartment of Urology, Institute of Medical Sciences, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea.
Eun-Taek HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea.
Jin-Hee HanDepartment of Medical Environmental Biology and Tropical Medicine, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea.
Wanjoo ChunDepartment of Pharmacology, Kangwon National University School of Medicine, Chuncheon, 24341, South Korea.
Won-Kyo JungDepartment of Biomedical Engineering, and Center for Marine-Integrated Biomedical Technology (BK21 Plus), Pukyong National University, Busan, 48513, South Korea.
Il-Whan ChoiDepartment of Microbiology, College of Medicine, Inje University, Busan, 48516, South Korea.
Won Sun ParkDepartment of Physiology, Institute of Medical Sciences, Kangwon National University School of Medicine, 1 Kangwondaehak-Gil, Chuncheon, 24341, South Korea. parkws@kangwon.ac.kr.ORCID http://orcid.org/0000-0001-5868-3797

Funding

National Research Foundation of Korea (NRF) 2021-R1A4A1031574National Research Foundation of Korea (NRF) 2021-R1A6A1A03039211National Research Foundation of Korea (NRF) RS-2023-00239172
6 · The paper itself

Abstract

aimsThe present study investigated the vasorelaxant mechanisms of an oral antidiabetic drug, anagliptin, using phenylephrine (Phe)-induced pre-contracted rabbit aortic rings.

methodsArterial tone measurement was performed in rabbit thoracic aortic rings.

resultsAnagliptin induced vasorelaxation in a dose-dependent manner. Pre-treatment with the classical voltagedependent K

conclusionsBased on these results, we suggest that anagliptin-induced vasorelaxation in rabbit aortic smooth muscle occurs by activating Kv channels and the SERCA pump, independent of other vascular K

Indexed as

AortaAorta, ThoracicHypoglycemic AgentsPotassium Channels, Voltage-GatedPyrimidinesSarcoplasmic Reticulum Calcium-Transporting ATPasesVasodilationVasodilator AgentsAnimalsMaleRabbitsHypoglycemic AgentsPotassium Channels, Voltage-GatedPyrimidinesSarcoplasmic Reticulum Calcium-Transporting ATPasesVasodilator AgentsAnagliptinAortaSERCA pumpVasorelaxationVoltage-dependent K+ channel

Identifiers

PMID39103505

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.