Evidence map›Paper›PMID 39103330›Full record

ArticleNature communications2024

Reprogramming the myocardial infarction microenvironment with melanin-based composite nanomedicines in mice.

Yamei Liu, Shuya Wang, Jiaxiong Zhang, Quan Sun, Yi Xiao, Jing Chen, Meilian Yao, Guogang Zhang, Qun Huang, Tianjiao Zhao and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  19. Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yamei Liu *Department of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.ORCID 0009-0008-3126-4638
Shuya Wang *Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, P.R. China.
Jiaxiong ZhangDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.ORCID 0000-0002-7687-1529
Quan SunDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Yi XiaoDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Jing ChenDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Meilian YaoDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Guogang ZhangDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Qun HuangDepartment of Child Health Care, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, 410008, Hunan, P.R. China.ORCID 0009-0008-2836-5796
Tianjiao ZhaoXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, P.R. China.
Qiong HuangNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Xiaojing ShiNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China.
Can FengXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, P.R. China.
Kelong AiXiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, P.R. China. aikelong@csu.edu.cn.ORCID 0000-0002-9863-8963
Yongping BaiDepartment of Geriatric Medicine, Coronary Circulation Center, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. baiyongping@csu.edu.cn.ORCID 0000-0002-6355-5842

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82373871
6 · The paper itself

Abstract

Myocardial infarction (MI) has a 5-year mortality rate of more than 50% due to the lack of effective treatments. Interactions between cardiomyocytes and the MI microenvironment (MIM) can determine the progression and fate of infarcted myocardial tissue. Here, a specially designed Melanin-based composite nanomedicines (MCN) is developed to effectively treat MI by reprogramming the MIM. MCN is a nanocomposite composed of polydopamine (P), Prussian blue (PB) and cerium oxide (Ce

Indexed as

CeriumIndolesMelaninsMyocardial InfarctionNanomedicinePolymersAnimalsCellular MicroenvironmentDisease Models, AnimalFerrocyanidesMaleMiceMice, Inbred C57BLMyocytes, CardiacNanocompositesReactive Oxygen Speciesceric oxideCeriumferric ferrocyanideFerrocyanidesIndolesMelaninspolydopaminePolymersReactive Oxygen Species

Identifiers

PMID39103330
PMCPMC11300711

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.