Evidence map›Paper›PMID 39103303›Full record

SynthesisObesity reviews : an official journal of the International Association for the Study of Obesity2024

A systematic review and meta-analysis of loss-of-control eating in relation to cardiometabolic health components and inflammatory markers.

Meghan E Byrne, Lisa M Shank, Jason M Lavender, Mary Katy Higgins-Neyland, Alexander Rice, Regan S Sweeney, Candace Norton, Mark Haigney, Jack A Yanovski, Marian Tanofsky-Kraff

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Prenatal loss of control eating and cardiovascular health: Extending prior findings.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meghan E ByrneSection on Development and Affective Neuroscience, Emotion and Development Branch, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, MD, USA.
Lisa M ShankDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Jason M LavenderDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Mary Katy Higgins-NeylandDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Alexander RiceDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Regan S SweeneyDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Candace NortonLearning Resource Center, USUHS, Bethesda, MD, USA.
Mark HaigneyDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.
Jack A YanovskiSection on Growth and Obesity, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Division of Intramural Research, National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0001-8542-1637
Marian Tanofsky-KraffDepartment of Medicine, Military Cardiovascular Outcomes Research (MiCOR) Program, Uniformed Services University of the Health Sciences (USUHS), Bethesda, MD, USA.

Funding

fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Physiology, Psychology, and Genetics of ObesityZ01HD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 1996 to 2008
$4.6M
Defense Health Agency MED 83-10180Eunice Kennedy Shriver National Institute of Child Health and Human Development ZIA-HD-00641Intramural NIH HHS Z01 HD000641Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000641Intramural NIH HHS ZIA MH002781NIMH NIH HHS ZIAMH002781
6 · The paper itself

Abstract

introductionLoss-of-control (LOC) eating, or the subjective experience of being unable to stop eating, is a hallmark feature of binge-eating episodes, which are also characterized by consuming an unusually large amount of food. However, regardless of the size of eating episode, LOC-eating may be a risk factor for adverse health outcomes. This systematic review and meta-analysis comprehensively examine the relationship of LOC-eating with cardiometabolic health components and inflammatory markers.

methodsSearch procedures were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines in six electronic databases. Studies of adult or youth samples published in English from the year 2000 onward were included. Given heterogeneity in age groups and adjustment for body mass index across studies, these factors were included as meta-regression moderators.

resultsFifty-eight studies were identified through the literature search. Among individuals with (versus without) LOC-eating, relative risk ratios provided evidence of a greater relative risk for metabolic syndrome, hypertension, and dyslipidemia; standardized mean differences also provided evidence of higher waist circumference and impaired levels of fasting plasma glucose, high-density lipoprotein (HDL)-cholesterol, and triglycerides, but not blood pressure. Age group did not impact cardiometabolic health components. Body mass index differences moderated the effect on waist circumference. A narrative review of inflammatory markers revealed mixed findings linking inflammatory markers to LOC-eating. DISCUSSION: Overall, evidence for the relationship between LOC-eating and impaired cardiometabolic health underscores LOC-eating as an important early intervention target for prevention of serious adverse health outcomes.

Indexed as

BiomarkersCardiometabolic Risk FactorsFeeding BehaviorCardiovascular DiseasesHumansInflammationMetabolic SyndromeRisk FactorsBiomarkersbinge‐eatingcardiometabolicinflammatory markersloss‐of‐control eating

Identifiers

PMID39103303
PMCPMC12278275

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.