Evidence map›Paper›PMID 39102798›Full record

ArticleLifestyle genomics2024

Interplay of Large Neutral Amino Acids, Metabolic Syndrome, and Apolipoprotein E ε4 on Brain Integrity at Midlife.

Cherry Youn, Marie L Caillaud, Yanrong Li, Isabelle Gallagher, Barbara Strasser, Hirofumi Tanaka, Andreana P Haley

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lifestyle genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cherry YounDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Marie L CaillaudDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Yanrong LiDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Isabelle GallagherDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.
Barbara StrasserFaculty of Medicine, Sigmund Freud Private University Vienna, Vienna, Austria.
Hirofumi TanakaDepartment of Kinesiology and Health Education, The University of Texas at Austin, Austin, Texas, USA.
Andreana P HaleyDepartment of Psychology, The University of Texas at Austin, Austin, Texas, USA.

Funding

Neuroimaging Cognitive Vulnerability in HypertensionR01NS075565 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI HALEY, ANDREANA PETROVA · 2011 to 2013
$986k
NINDS NIH HHS R01 NS075565
6 · The paper itself

Abstract

introductionLarge neutral amino acids (LNAAs) tryptophan and phenylalanine have been implicated in the pathogenesis of neurodegenerative diseases. Given limited research on the effects of LNAA on brain health across different life stages, vascular risk, and genetic backgrounds, our study aimed to explore the interaction of LNAA levels, metabolic syndrome (MetS), and the presence of the apolipoprotein E ε4 (ApoE ε4) allele brain integrity at midlife.

methodsSixty-eight adults aged 40-61 underwent a health assessment to calculate the number of MetS components, quantify LNAA, measure white matter hyperintensity (WMH) volume, and genotype ApoE ε4. Multivariate linear regression analyses were performed to test the joint effect of LNAA, MetS, and ApoE ε4 on WMH while adjusting for sex, age, and education.

resultsSignificant 3-way interactions were observed between serum tryptophan (β = 0.042, SE = 0.018, p < 0.05) and phenylalanine (β = 0.044, SE = 0.013, p < 0.01) levels, number of MetS components, and ApoE ε4 alleles status on WMH volume. Neither individual LNAA levels nor MetS components alone predicted WMH volume.

conclusionsThe study highlights significant 3-way interactions between LNAA, MetS, and genetic risk factors in the pathology of WMH, particularly in individuals genetically predisposed to Alzheimer's disease. These interactions suggest differential impacts of LNAA on WMH volume dependent on both genetic and metabolic factors. Results emphasize the need for personalized metabolic and genetic profile assessments in neurodegenerative disease management.

Indexed as

Apolipoprotein E4BrainMetabolic SyndromeTryptophanAdultAllelesAmino Acids, NeutralFemaleGenotypeHumansMagnetic Resonance ImagingMaleMiddle AgedPhenylalanineWhite MatterAmino Acids, NeutralApolipoprotein E4PhenylalanineTryptophanApoE4Brain integrityLarge neutral amino acidsMetabolic syndromeMidlife adults

Identifiers

PMID39102798
PMCPMC11385466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.