Evidence map›Paper›PMID 39102520›Full record

ArticleAngewandte Chemie (International ed. in English)2024

DNA-Intercalating Supramolecular Hydrogels for Tunable Thermal and Viscoelastic Properties.

Shaina M Hughes, Aylin Aykanat, Nicholas G Pierini, Wynter A Paiva, April A Weeks, Austin S Edwards, Owen C Durant, Nathan J Oldenhuis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Design and Characterization of DX-Tile DNA Nanostar-Based Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shaina M HughesDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Aylin AykanatDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Nicholas G PieriniDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Wynter A PaivaDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
April A WeeksDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Austin S EdwardsDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Owen C DurantDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.
Nathan J OldenhuisDepartment of Chemistry, College of Engineering and Physical Science, University of New Hampshire, 23 Academic Way, Parsons Hall, Durham, NH 03824, United States of America.ORCID 0000-0003-4256-0826

Funding

TLR-TRIF mediated induction of GLI3 modulates innate inflammatory responsesP20GM113131 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI DON Michael WOJCHOWSKI · 2017 to 2026
$22.8M
Using DNA hydrogels to mimic, exploit, and fundamentally investigate extracellular matricesR35GM154998 · NIGMS · UNIVERSITY OF NEW HAMPSHIRE · PI Nathan John Oldenhuis · 2024 to 2026
$1.1M
National Science Foundation 1757371National Science Foundation 2340569NIGMS NIH HHS 1R35GM154998NIGMS NIH HHS P20 GM113131NIGMS NIH HHS P20GM113131NIGMS NIH HHS R35 GM154998
6 · The paper itself

Abstract

Polymeric supramolecular hydrogels (PSHs) leverage the thermodynamic and kinetic properties of non-covalent interactions between polymer chains to govern their structural characteristics. As these materials are formed via endothermic or exothermic equilibria, their thermal response is challenging to control without drastically changing the nature of the chemistry used to join them. In this study, we introduce a novel class of PSHs utilizing the intercalation of double-stranded DNA (dsDNA) as the primary dynamic non-covalent interaction. The resulting dsDNA intercalating supramolecular hydrogels (DISHs) can be tuned to exhibit both endothermically or exothermically driven binding through strategic selection of intercalators. Bifunctional polyethylene glycol (M

Indexed as

DNAHydrogelsIntercalating AgentsElasticityPolyethylene GlycolsTemperatureThermodynamicsViscosityDNAHydrogelsIntercalating AgentsPolyethylene GlycolsBiomaterialsDNA IntercalationsEntropy driven gelationSupramolecular hydrogels

Identifiers

PMID39102520
PMCPMC11956831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.