ArticlePLoS neglected tropical diseases2024
Hepatitis E virus in the Kathmandu Valley: Insights from a representative longitudinal serosurvey.
Article in PLoS neglected tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A flexible class of latent variable models for the analysis of antibody response data.Biostatistics (Oxford, England) · 2026Article
- Serological and molecular characterization of hepatitis E virus and co-infections during the 2014 Biratnagar outbreak in Nepal.BMC infectious diseases · 2025Article
- Geospatial distribution of Hepatitis E seroprevalence in Nepal, 2021.PLoS neglected tropical diseases · 2024Article
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9 authors.
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Abstract
backgroundHepatitis-E virus (HEV), an etiologic agent of acute inflammatory liver disease, is a significant cause of morbidity and mortality in South Asia. HEV is considered endemic in Nepal; but data on population-level infection transmission is sparse.
methodsWe conducted a longitudinal serosurvey in central Nepal to assess HEV exposure. At each visit, capillary blood samples were collected and analyzed for the presence of anti-HEV IgG antibodies. The study took place between February 2019 and April 2021, with up to 4 visits per participant approximately 6 months apart.
resultsWe collected 2513 samples from 923 participants aged 0-25 years, finding a seroprevalence of 4.8% and a seroincidence rate of 10.9 per 1000 person-years. Young adults and individuals consuming surface water faced the highest incidence of infection. Geospatial analysis identified potential HEV clusters, suggesting a need for targeted interventions. SIGNIFICANCE: Our findings demonstrate that HEV is endemic in Nepal and that the risk of infection increases with age.
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