Evidence map›Paper›PMID 39102433›Full record

ArticlePLoS neglected tropical diseases2024

Acute Q fever in patients with an influenza-like illness in regional New South Wales, Australia.

Chaturaka Rodrigo, Gregory Walker, Andrea T K Sevendal, Chelsea Nguyen, Sacha Stelzer-Braid, William Rawlinson, Stephen Graves, Heather F Gidding, John Stenos, Andrew R Lloyd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS neglected tropical diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chaturaka RodrigoSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-2189-9177
Gregory WalkerSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Andrea T K SevendalNSW Health Pathology, Prince of Wales Hospital, Randwick, New South Wales, Australia.
Chelsea NguyenAustralian Rickettsial Reference Laboratory, Geelong, Victoria, Australia.
Sacha Stelzer-BraidSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
William RawlinsonSchool of Biomedical Sciences, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
Stephen GravesAustralian Rickettsial Reference Laboratory, Geelong, Victoria, Australia.
Heather F GiddingSchool of Population Health, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.
John StenosAustralian Rickettsial Reference Laboratory, Geelong, Victoria, Australia.
Andrew R LloydKirby Institute, Faculty of Medicine and Health, University of New South Wales, Sydney, New South Wales, Australia.

Funding

CSL Seqirus Australia QFE-21-001-RODRIGO
6 · The paper itself

Abstract

introductionQuery (Q) fever is a zoonosis caused by the bacterium Coxiella burnetii typically presenting as an influenza-like illness (ILI) with or without hepatitis. The infection may be missed by clinicians in settings of low endemicity, as the presentation is clinically not specific, and there are many more common differential diagnoses for ILI including SARS-CoV-2 infection.

methodsResidual serum samples were retrospectively tested for Phase 1 and 2 Q fever-specific IgM, IgG, IgA antibodies by indirect immunofluorescence and C. burnetii DNA by polymerase chain reaction. They had not been previously tested for Q fever, originating from undiagnosed patients with probable ILI, aged 10-70 years and living in regional New South Wales, Australia. The results were compared with contemperaneous data on acute Q fever diagnostic tests which had been performed based on clinicians requests from a geographically similar population.

resultsOnly one (0.2%) instance of missed acute Q fever was identified after testing samples from 542 eligible patients who had probable ILI between 2016-2023. Laboratory data showed that during the same period, 731 samples were tested for acute Q fever for clinician-initiated requests and of those 70 (9.6%) were positive. Probability of being diagnosed with Q fever after a clinician initiated request was similar regardless of the patients sex, age and the calendar year of sampling.

conclusionIn this sample, Q fever was most likely to be diagnosed via clinician requested testing rather than by testing of undiagnosed patients with an influenza like illness.

Indexed as

Coxiella burnetiiInfluenza, HumanQ FeverAdolescentAdultAgedAntibodies, BacterialChildCOVID-19Diagnosis, DifferentialFemaleHumansImmunoglobulin MMaleMiddle AgedNew South WalesAntibodies, BacterialImmunoglobulin M

Identifiers

PMID39102433
PMCPMC11326637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.