Evidence map›Paper›PMID 39102170›Full record

ArticleJournal of echocardiography2025

The Multicenter STudy On a Precise algorithm for diagnosis of heart failure with preserved ejection fraction, STOP-HFPEF study: study protocol and design.

Tadafumi Sugimoto, Yu Kawada, Shohei Kikuchi, Shuichi Kitada, Masao Daimon, Yutaka Hirano, Masaki Izumo, Toshinari Onishi, Masaru Obokata, Hiroto Utsunomiya and 1 more

Abstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Journal of echocardiography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tadafumi SugimotoDepartments of Cardiology, Nagoya City University Mirai Kousei Hospital, 2-1501 Sekobou, Nagoya, 465-8650, Japan. t_sugimoto_japan@hotmail.com.ORCID http://orcid.org/0000-0002-9016-2120
Yu KawadaDepartment of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Nagoya, 467-8601, Japan.
Shohei KikuchiDepartment of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Nagoya, 467-8601, Japan.
Shuichi KitadaDepartment of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Nagoya, 467-8601, Japan.
Masao DaimonDepartment of Cardiology, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Yutaka HiranoFaculty of Medicine, Center for Medical Education and Clinical Training, Kindai University, 377-2 Ohnohigasi, Osakasayama, Osaka, 589-8511, Japan.
Masaki IzumoDepartment of Cardiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa, 216-8511, Japan.
Toshinari OnishiDepartment of Cardiovascular Medicine, Sakai City Medical Center, 1-1-1 Ebaraji-cho, Nishi-ku, Sakai City, Osaka, 593-8304, Japan.
Masaru ObokataDepartment of Cardiovascular Medicine, Gunma University Graduate School of Medicine, 3-39-22 Showa-Machi, Maebashi, Gunma, 371-8511, Japan.
Hiroto UtsunomiyaDepartment of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan.
Yoshihiro SeoDepartment of Cardiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Nagoya, 467-8601, Japan.

Funding

Japan Society for the Promotion of Science 22K08132
6 · The paper itself

Abstract

This study aims to develop a new heart failure with preserved ejection fraction (HFpEF) diagnostic algorithm tailored to Asian populations, addressing limitations of current diagnostic models. Existing HFpEF diagnostic algorithms primarily target patients with dyspnea and metabolic comorbidities, such as obesity, which are more prevalent in Western populations. However, in Asian countries, HFpEF cases are less frequently associated with obesity, leading to less prominent dyspnea and more noticeable symptoms such as fatigue. By incorporating exercise stress echocardiography and focusing on early-stage HFpEF, particularly in patients with symptoms beyond dyspnea, we seek to enable early diagnosis and intervention, ultimately extending healthy life expectancy and improving quality of life. The STOP-HFPEF (The Multicenter STudy On a Precise algorithm for diagnosis of Heart Failure with Preserved Ejection Fraction) study is a multicenter prospective observational investigation in Japan. Certified by the Japanese Society of Echocardiography, the study includes participants aged 20 and older who undergo exercise stress echocardiography. The primary goal is to develop a scoring model for diagnosing HFpEF in heart-failure stages A, B, and C. Secondary outcomes will assess the clinical utility of the new diagnostic score by comparing heart-failure incidence, cardiovascular events, and mortality rates.Study registration: Registered at the UMIN registry (UMIN000054565) on 1 July 2024.

Indexed as

AlgorithmsEchocardiography, StressHeart FailureStroke VolumeAdultAgedFemaleHumansJapanMaleMiddle AgedMulticenter Studies as TopicObservational Studies as TopicProspective StudiesQuality of LifeDiagnosisExercise stress echocardiographyHeart failure with preserved ejection fractionStudy protocol

Identifiers

PMID39102170

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.