ArticlePain and therapy2024
Change in Endogenous Pain Modulation Depending on Emotional States in Healthy Subjects: A Randomized Controlled Trial.
Article in Pain and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Effect ofNutrients · 2026Trial
- Effects of empowered relief on pain catastrophizing and outcomes post-total knee arthroplasty: A quasi-experimental study.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2026Article
- Liposuction for Lipedema Significantly Reduces Benzodiazepine Dependence: A Prospective Cohort Study.Aesthetic plastic surgery · 2026Observational
- Association Between Smoking and Opioid Requirement and Pain Intensity in the Early Postoperative Period: A Meta-Analysis.Pain and therapy · 2026Article
- Social conflict imagery induces stress, social and physical pain: sex differences in autonomic and affective responses and pathways to resilience and wellbeing.Frontiers in psychology · 2026Article
- The Impact of Catastrophization and Emotions on Pain: A Narrative Review of Underlying Mechanisms.Journal of pain research · 2026Review
- Intact endogenous pain inhibition in complex regional pain syndrome type 1.Pain reports · 2025Article
- Investigating the relationship between temporomandibular disorders and personality traits.Journal of oral & facial pain and headache · 2025Observational
- Neck pain and emotional state in cervical spondylosis: A dual trajectory model analysis.World journal of psychiatry · 2025Article
- The analgesic effect and neural mechanism of spicy food intake.Social cognitive and affective neuroscience · 2025Article
- Neural basis of intensity-dependent brain activity in response to mechanical stimulation and the level of pain sensitivity.Frontiers in human neuroscience · 2025Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionChronic pain is a public health issue, leading to substantial healthcare costs and diminished quality of life for sufferers. While the role of anxiety in pain modulation has been extensively studied, the effects of other emotional states on the body's pain control mechanisms remain less understood. This study sought to explore how different emotions (happiness, anger, sadness, and interest) affect conditioned pain modulation (CPM) and the wind-up phenomenon in healthy adults.
methodsThis randomized controlled, cross-over trial involved 28 healthy participants aged 18-60. Participants watched video clips designed to induce specific emotions: happiness, anger, sadness, and interest. Emotional states were assessed using a 7-point Likert scale. Pain modulation was measured using CPM and the wind-up phenomenon. CPM was assessed with a hot water bath as the conditioning stimulus and pressure pain tolerance as the test stimulus. Wind-up was measured using pinprick needle stimulators and a visual analog scale. Data were analyzed using paired t tests to compare pre- and post-emotion induction values.
resultsSignificant changes in emotional self-assessment values were observed for all emotions. Happiness increased CPM (4.6 ± 11.4, p = 0.04277), while sadness - 9.9 ± 23.1, p = 0.03211) and anger - 9.1 ± 23.3, p = 0.04804) decreased it. Interest did not significantly alter CPM (- 5.1 ± 25.8, p = 0.31042). No significant effects were found for the wind-up phenomenon across any emotional states.
conclusionThis study shows that emotional states significantly affect the body's ability to modulate pain. Positive emotions like happiness enhance pain inhibition, while negative emotions such as sadness and anger impair it. These findings suggest that emotional modulation techniques could be integrated into pain management strategies to improve patient outcomes. Further research should explore a broader range of emotions and include objective measures to validate these results.
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