Evidence map›Paper›PMID 39102075›Full record

ArticleThe international journal of cardiovascular imaging2024

Effect of acute intravenous beta-blocker administration on myocardial blood flow during same-day hybrid CCTA/PET imaging.

Marko Gajic, Andrei Galafton, Pascal S Heiniger, Tobia Albertini, Stjepan Jurisic, Catherine Gebhard, Dominik C Benz, Aju P Pazhenkottil, Andreas A Giannopoulos, Philipp A Kaufmann and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of cardiovascular imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marko GajicDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Andrei GalaftonDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Pascal S HeinigerDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Tobia AlbertiniDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Stjepan JurisicDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Catherine GebhardDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Dominik C BenzDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Aju P PazhenkottilDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Andreas A GiannopoulosDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Philipp A KaufmannDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland.
Ronny R BuechelDepartment of Nuclear Medicine, Cardiac Imaging, University and University Hospital Zurich, NUK A 12 Ramistrasse 100, 8091, Zurich, Switzerland. ronny.buechel@usz.ch.ORCID http://orcid.org/0000-0001-8064-8904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the impact of acute intravenous beta-blocker administration on myocardial blood flow (MBF) during same-day hybrid coronary computed tomography angiography (CCTA) and 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). Previous research on the discontinuation of oral beta-blockers before MPI has shown mixed results, with no studies yet exploring the acute intravenous administration in the context of same-day hybrid imaging. This retrospective study included patients with suspected chronic coronary syndromes undergoing same-day hybrid CCTA/13N-ammonia PET MPI. Exclusion criteria comprised coronary artery stenosis ≥ 50% or regional perfusion abnormalities on PET, and baseline oral beta-blocker medication. Intravenous metoprolol (up to 30 mg) was administered as needed for heart rate control before CCTA. MBF measurements were obtained at rest (rMBF) and during stress (sMBF), and myocardial flow reserve (MFR) was calculated. After excluding 281 patients, 154 were eligible for propensity-score matching, resulting in 108 patients divided into two equal groups based on beta-blocker administration. The groups showed no significant differences in baseline characteristics. Among those who received beta-blockers, there was a significant decrease in sMBF (2.21 [IQR 1.72-2.78] versus 2.46 [2.08-2.99] ml∙min

Indexed as

Coronary AngiographyCoronary CirculationMetoprololMyocardial Perfusion ImagingPredictive Value of TestsRadiopharmaceuticalsAdministration, IntravenousAdrenergic beta-AntagonistsAgedAmmoniaComputed Tomography AngiographyCoronary Artery DiseaseCoronary VesselsDrug Administration ScheduleFemaleHumansAdrenergic beta-AntagonistsAmmoniaMetoprololNitrogen RadioisotopesRadiopharmaceuticalsBeta-blockersCoronary CT angiographyHybrid imagingIntravenousMyocardial blood flowPositron emission tomography

Identifiers

PMID39102075
PMCPMC11499384

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.